지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 704 - 712 (9page)
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This study was designed to examine the effects of bitter melon (BM) on the plasma blood glucose and cholesterol levels in diabetic rats. Diabetes mellitus was induced in male Sprague-Dawley rats through an injection of streptozotocin (STZ) dissolved in a citrate buffer into the tail vein at a dose of 45 mg/kg of body weight. Sprague-Dawley rats were then fed for four weeks, with the experimental groups receiving a modified diet containing 5% or 10% powder derived from BM. The experimental groups were divided into 4 groups, consisting of the normal control group, STZ-control group and diabetic fed with BM 5% & 10% treated groups. The rats’ body weight, blood glucose and cholesterol values were measured along with the hematocrit (Hct) values and aminotransferase activities. Body weight losses were observed in the diabetic groups, whereas the control rats gained weight. There were significant differences in kidney weight between the control group and the diabetic groups. The Hct levels of the diabetic BM-treated group were significantly higher than the STZ-control group. Aspartate aminotransferase activity was lower in the non-diabetic group compared to the diabetic experimental groups. Further, the blood glucose was significantly decreased in the 5% & 10% BM of the diabetic group. There were no significant difference in cholesterol levels among the diabetic groups. These results indicate that the supplementation of bitter melon may have a favorable influence on reducing the blood glucose level in STZ-induced diabetic rats.
목차
Abstract
서론
재료 및 방법
결과 및 고찰
결론
문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Ahmed I / 2001 / Hypotriglyceridemic and hypocholesterolemic effects of anti- diabetic Momordica charantia (karela) fruit extract in strep- tozotocin-induced diabetic rats / Diabetes Res Clin Pract 51 : 155 ~ 161
2. [학술지(정기간행물)] - Allain CC / 1974 / Enzymatic determination of total serum cholesterol / Clin Chem 20 : 470 ~ 475
3. [단행본] - Bauer JD / 1982 / Clinical laboratory methods / Mosby Co. : 188 ~ 189
4. [학술지(정기간행물)] - Brooks DP / 1989 / Vasopre- ssin in rats with genetic and streptozotocin-induced diabetes / Diabetes 38 : 54 ~ 57
5. [학술지(정기간행물)] - Choi JW / 1991 / The effects of nicotin- amide on the serum lipid composition in streptozotocin- induced diabetic rats / J Korean Soc Food Nutr 20 : 306 ~ 311
2. [학술지(정기간행물)] - Allain CC / 1974 / Enzymatic determination of total serum cholesterol / Clin Chem 20 : 470 ~ 475
3. [단행본] - Bauer JD / 1982 / Clinical laboratory methods / Mosby Co. : 188 ~ 189
4. [학술지(정기간행물)] - Brooks DP / 1989 / Vasopre- ssin in rats with genetic and streptozotocin-induced diabetes / Diabetes 38 : 54 ~ 57
5. [학술지(정기간행물)] - Choi JW / 1991 / The effects of nicotin- amide on the serum lipid composition in streptozotocin- induced diabetic rats / J Korean Soc Food Nutr 20 : 306 ~ 311
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UCI(KEPA) : I410-ECN-0101-2015-590-001038940