지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 58 - 66 (9page)
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초록· 키워드
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Purpose: The inferior alveolar nerve (IAN) can be damaged as a result of minor oral surgical procedure such as third molar extraction or implant placement. Repair of the injured IAN involves difficulty of access, and research studies are limited to elucidating the process of regeneration by surgical methods. This study sought to establish the rabbit animal model to apply polymeric membrane functionalized with nerve growth factor after a crush lesion for the evaluation of nerve regeneration using the electrophysiologic method.
Materials and Methods: The IAN of 2 adult male New Zealand white rabbits (4 nerves) were exposed bilaterally, and crush injury rendered by jeweler’s forceps was applied. Nerve conduction velocity was examined electrophysiologically using electromyography before, after, and 4 weeks after the crush injury. To evaluate the regeneration, the pattern of action potential of IAN was recorded, and the characteristics of neurons were histologically observed.
Result: After the crush injury, afferent activity decreased in the injured group. Electromyography could not be recorded after four weeks because tissues surrounding the injured nerve collapsed. Decrease in the mean number of axons was observed in the injured part with membrane.
Conclusion: Despite the limited result, the present animal model study may provide a possible way to research on the methods of enhancing the recovery of nerve injuries in clinical situations. For clinically widespread acceptance, however, it should gain more consecutive and scientific evidences.
Materials and Methods: The IAN of 2 adult male New Zealand white rabbits (4 nerves) were exposed bilaterally, and crush injury rendered by jeweler’s forceps was applied. Nerve conduction velocity was examined electrophysiologically using electromyography before, after, and 4 weeks after the crush injury. To evaluate the regeneration, the pattern of action potential of IAN was recorded, and the characteristics of neurons were histologically observed.
Result: After the crush injury, afferent activity decreased in the injured group. Electromyography could not be recorded after four weeks because tissues surrounding the injured nerve collapsed. Decrease in the mean number of axons was observed in the injured part with membrane.
Conclusion: Despite the limited result, the present animal model study may provide a possible way to research on the methods of enhancing the recovery of nerve injuries in clinical situations. For clinically widespread acceptance, however, it should gain more consecutive and scientific evidences.
목차
Introduction
Materials and Methods
Result
Discussion
Conclusion
References
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Gregg JM / 1995 / Surgical management of inferior alveolar nerve injuries (Part II): the case for delayed management / J Oral Maxillofac Surg 53 : 1330 ~ 1333
2. [학술지(정기간행물)] - Renton T / 2012 / Managing iatrogenic trigeminal nerve injury: a case series and review of the literature / Int J Oral Maxillofac Surg 41 : 629 ~ 637
3. [학술지(정기간행물)] - Vougioukas VI / 2001 / Effects of the immunomodulator linomide on macrophage migration and myelin phagocytic activity in peripheral nerve trauma: an experimental study / J Neurotrauma 18 : 555 ~ 562
4. [학술지(정기간행물)] - Gaudet AD / 2011 / Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury / J Neuroinflammation 8 : 110 ~
5. [학술지(정기간행물)] - Brück W. / 1997 / The role of macrophages in Wallerian degeneration / Brain Pathol 7 : 741 ~ 752
2. [학술지(정기간행물)] - Renton T / 2012 / Managing iatrogenic trigeminal nerve injury: a case series and review of the literature / Int J Oral Maxillofac Surg 41 : 629 ~ 637
3. [학술지(정기간행물)] - Vougioukas VI / 2001 / Effects of the immunomodulator linomide on macrophage migration and myelin phagocytic activity in peripheral nerve trauma: an experimental study / J Neurotrauma 18 : 555 ~ 562
4. [학술지(정기간행물)] - Gaudet AD / 2011 / Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury / J Neuroinflammation 8 : 110 ~
5. [학술지(정기간행물)] - Brück W. / 1997 / The role of macrophages in Wallerian degeneration / Brain Pathol 7 : 741 ~ 752
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UCI(KEPA) : I410-ECN-0101-2015-510-001009698