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논문 기본 정보

자료유형
학술저널
저자정보
(Jeju National University) (Jeju National University) (Jeju National University) (Jeju National University) (Jeju National University)
저널정보
충북대학교 동물의학연구소 Journal of Biomedical Research Journal of Biomedical Research Vol.14 No.4
발행연도
수록면
220 - 225 (6page)

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초록· 키워드

Our previous research on sulfated polysaccharide purified from Ecklonia cava, a brown alga found in Jeju island, Korea, showed that sulfated polysaccharides modulate the apoptotic threshold of intestinal cells, thereby preventing intestinal damage caused by ionizing radiation. In this study, we investigated the ability of sulfated polysaccharide to augment restoration of small intestinal stem cells from γ-ray-induced damage. In our results, sulfated polysaccharide treatment increased the numbers of Ki-67-positive cells as well as inducible nitric oxide synthase (iNOS)-expressing cells in the small intestine compared with those of irradiated only mice. Meanwhile, exposure to irradiation increased the number of paneth cells, which are frequently associated with intestinal inflammation, whereas sulfated polysaccharide treatment reduced the number of paneth cells in the small intestinal crypt. Conclusively, our data suggest that reduction of iNOS-expressing cells and paneth cells in sulfated polysaccharide-treated mice contributes to the inhibition of radiation-induced intestinal inflammation.
#sulfated polysaccharide #irradiation #intestinal stem cell #paneth cell #intestinal inflammation
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목차

  1. Introduction
  2. Materials and Methods
  3. Results
  4. Conclusion
  5. References

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