지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.85 No.6
- 발행연도
- 2013.12
- 수록면
- 296 - 301 (6page)
이용수
초록· 키워드
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Purpose: Inhibition of the intimal hyperplasia after vascular surgery is an important issue. The purpose of this study is to define whether perivascular application of rapamycin, imatinib mesylate or cysteamine can reduce intimal hyperplasia in a carotid balloon injury model.
Methods: Each drug was mixed with 40% pluronic gel solution and was topically applied over the injured carotid artery evenly. Two or four weeks after injury, the arteries were harvested and morphometric analysis was done.
Results: The medial areas were not significantly different in each group and a thinning of the media as a toxic drug effect was not observed in any treatment group. The intimal area and intima-to-media (I/M) ratio were significantly reduced in rapamycin-treated group and imatinib-treated group (P < 0.05). But cysteaminetreated group showed a trend of decrease in I/M ratio in 2 weeks, but no difference in 4 weeks.
Conclusion: Perivascular delivery of imatinib or rapamycin with pluronic gel attenuated the development of intimal hyperplasia. But cysteamine did not. Further studies are needed to refine the optimal drug dosages in large animal models.
Methods: Each drug was mixed with 40% pluronic gel solution and was topically applied over the injured carotid artery evenly. Two or four weeks after injury, the arteries were harvested and morphometric analysis was done.
Results: The medial areas were not significantly different in each group and a thinning of the media as a toxic drug effect was not observed in any treatment group. The intimal area and intima-to-media (I/M) ratio were significantly reduced in rapamycin-treated group and imatinib-treated group (P < 0.05). But cysteaminetreated group showed a trend of decrease in I/M ratio in 2 weeks, but no difference in 4 weeks.
Conclusion: Perivascular delivery of imatinib or rapamycin with pluronic gel attenuated the development of intimal hyperplasia. But cysteamine did not. Further studies are needed to refine the optimal drug dosages in large animal models.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Bauters C / 1997 / The biology of restenosis / Prog Cardiovasc Dis 40 : 107 ~ 116
2. [학술지(정기간행물)] - Kester M / 2001 / New strategies to prevent restenosis / Am J Cardiovasc Drugs 1 : 77 ~ 83
3. [학술지(정기간행물)] - Clowes AW / 1983 / Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium / Lab Invest 49 : 327 ~ 333
4. [학술지(정기간행물)] - Min SK / 2008 / Induction of vascular atrophy as a novel approach to treating restenosis: a review / J Vasc Surg 47 : 662 ~ 670
5. [학술지(정기간행물)] - Moses JW / 2003 / O’Shaughnessy C, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery / N Engl J Med 349 : 1315 ~ 1323
2. [학술지(정기간행물)] - Kester M / 2001 / New strategies to prevent restenosis / Am J Cardiovasc Drugs 1 : 77 ~ 83
3. [학술지(정기간행물)] - Clowes AW / 1983 / Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium / Lab Invest 49 : 327 ~ 333
4. [학술지(정기간행물)] - Min SK / 2008 / Induction of vascular atrophy as a novel approach to treating restenosis: a review / J Vasc Surg 47 : 662 ~ 670
5. [학술지(정기간행물)] - Moses JW / 2003 / O’Shaughnessy C, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery / N Engl J Med 349 : 1315 ~ 1323
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UCI(KEPA) : I410-ECN-0101-2015-510-000972845