지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 22 - 27 (6page)
이용수
초록· 키워드
오류제보하기
Background: Research has been conducted with regard to the development of methods for improving the pharmaceutical effect of ginseng by conversion of ginsenosides, which are the major active components of ginseng, via high temperature or high-pressure processing.
Methods: The present study sought to investigate the anticancer effect of heat-processed American ginseng (HAG) in human gastric cancer AGS cells with a focus on assessing the role of apoptosis as an important mechanistic element in its anticancer actions.
Results and Conclusion: HAG significantly reduced the cancer cell proliferation, and the contents of ginsenosides Rb1 and Re were markedly decreased, whereas the peaks of less-polar ginsenosides [20(S,R)-Rg3, Rk1, and Rg5] were newly detected. Based on the activity-guided fractionation of HAG, ginsenoside 20(S)-Rg3 played a key role in inducing apoptosis in human gastric cancer AGS cells, and it was generated mainly from ginsenoside Rb1. Ginsenoside 20(S)-Rg3 induced apoptosis through activation of caspase-3, caspase-8, and caspase-9, as well as regulation of Bcl-2 and Bax expression. Taken together, these findings suggest that heat-processing serves as an increase in the antitumor activity of American ginseng in AGS cells, and ginsenoside 20(S)-Rg3, the active component produced by heat-processing, induces the activation of caspase-3, caspase-8, and caspase-9, which contributes to the apoptotic cell death.
Methods: The present study sought to investigate the anticancer effect of heat-processed American ginseng (HAG) in human gastric cancer AGS cells with a focus on assessing the role of apoptosis as an important mechanistic element in its anticancer actions.
Results and Conclusion: HAG significantly reduced the cancer cell proliferation, and the contents of ginsenosides Rb1 and Re were markedly decreased, whereas the peaks of less-polar ginsenosides [20(S,R)-Rg3, Rk1, and Rg5] were newly detected. Based on the activity-guided fractionation of HAG, ginsenoside 20(S)-Rg3 played a key role in inducing apoptosis in human gastric cancer AGS cells, and it was generated mainly from ginsenoside Rb1. Ginsenoside 20(S)-Rg3 induced apoptosis through activation of caspase-3, caspase-8, and caspase-9, as well as regulation of Bcl-2 and Bax expression. Taken together, these findings suggest that heat-processing serves as an increase in the antitumor activity of American ginseng in AGS cells, and ginsenoside 20(S)-Rg3, the active component produced by heat-processing, induces the activation of caspase-3, caspase-8, and caspase-9, which contributes to the apoptotic cell death.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Yun TK / 2001 / Brief introduction of Panax ginseng C.A. Meyer / J Korean Med Sci 16 : 3 ~ 5
2. [학술지(정기간행물)] - Nocerino E / 2000 / The aphrodisiac and adaptogenic properties of ginseng / Fitoterapia 71 : 1 ~ 5
3. [학술지(정기간행물)] - Bent S / 2004 / Commonly used herbal medicines in the United States: a review / Am J Med 116 : 478 ~ 485
4. [학술지(정기간행물)] - Hu C / 2001 / Free radical scavenging capacity as related to antioxidant activity and ginsenoside composition of Asian and North American ginseng extracts / J Am Oil Chem Soc 78 : 249 ~ 255
5. [학술지(정기간행물)] - Kang KS / 2007 / Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation / J Ethnopharmacol 113 : 225 ~ 232
2. [학술지(정기간행물)] - Nocerino E / 2000 / The aphrodisiac and adaptogenic properties of ginseng / Fitoterapia 71 : 1 ~ 5
3. [학술지(정기간행물)] - Bent S / 2004 / Commonly used herbal medicines in the United States: a review / Am J Med 116 : 478 ~ 485
4. [학술지(정기간행물)] - Hu C / 2001 / Free radical scavenging capacity as related to antioxidant activity and ginsenoside composition of Asian and North American ginseng extracts / J Am Oil Chem Soc 78 : 249 ~ 255
5. [학술지(정기간행물)] - Kang KS / 2007 / Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation / J Ethnopharmacol 113 : 225 ~ 232
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2015-520-001297345