지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.2
- 수록면
- 42 - 49 (8page)
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초록· 키워드
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The aim of this study was to develop a composite human skin equivalent for wound healing. Collagen type1 and acellular dermal matrix powder were utilized as the scaffold with dermal fibroblasts and keratinocytes for the development of a composite human skin equivalent. Fibroblast maintained the volume of composite skin equivalent and also induced keratinocytes to attach and proliferate on the surface of composite skin equivalent. The composite human skin equivalent had a structure and curvature similar to those of real skin. Balb-C nu/nu mice were used for the evaluation of full-thickness wound healing effect of the composite human skin equivalent. Graft of composite skin equivalent on full-thickness wound promoted re-epithelialization and granulation tissue formation at 9 days. Given the average wound-healing time (14 days), the wound in the developed composite skin equivalent healed quickly. The overall results indicated that this three-dimensional composite human skin equivalent can be used to effectively enhance wound healing.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCES
참고문헌 (24)
참고문헌 신청
Darlenski, R. / 2011 / Skin barrier function: morphological basis and regulatory mechanisms / J. Clin. Med 4:36~45
Denda, M / 2000 / Skin barrier function as a self-organizing system / Forma 15:227~232
한승규 / 2011 / 우리나라의 최신 창상피복법 / 대한의사협회지 54(6):594~603
Tanner, J. C. / 1964 / The mesh skin graft / Plast. Reconstr. Surg 34:287~291
Rheinwald, J. G. / 1975 / Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells / Cell 6:331~344
Denda, M / 2000 / Skin barrier function as a self-organizing system / Forma 15:227~232
한승규 / 2011 / 우리나라의 최신 창상피복법 / 대한의사협회지 54(6):594~603
Tanner, J. C. / 1964 / The mesh skin graft / Plast. Reconstr. Surg 34:287~291
Rheinwald, J. G. / 1975 / Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells / Cell 6:331~344
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UCI(KEPA) : I410-ECN-0101-2015-400-001242910