지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Hypothyroidism is the most common disease in the endocrine system. Cistanche Deserticola has been used traditionally in the treatment of kidney deficiency and Yang deficiency syndrome. In this study, we investigated the therapeutic effects of Cistanche Deserticola on Hypothyroidism rat model induced by PTU. 24 Two-month-old Sprague-Dawley male rats were divided into 4 groups : 1) normal(n=6), 2) PTU-induced hypothyroidism control(n=6), 3) hypothyroidism rat treated with Cistanche Deserticola(n=6), 4) hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4 weeks. Cistanche Deserticola and levothyroxine was administered 2 weeks after PTU was initiated for a total duration of 2 week. Body weights were checked every week and after 4 weeks, biochemical analysis was performed and T3, T4 and TSH were measured by ELISA kits. In comparison with the normal group, the control group showed hypothyroidism with lower T3, T4 level and higher TSH level. In the Cistanche group the level of T4 was significantly increased and TSH level was significantly decreased. There was no significant difference in biochemical labs and weight between the Cistanche group and the control group. These findings suggest that Cistanche Deserticola could help the production of thyroid hormones under PTU suppression. And there is no harmful effect on liver and kidney function, and other metabolism. According to these results Cistanche Deserticola could be an useful agent for treating hypothyroidism.
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재료 및 방법
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참고문헌
참고문헌 (32)
참고문헌 신청
Gardner, D. / 2007 / Greenspan's basic and clinical endocrinology. 8th ed / McGraw-Hill Medical :210~248
대한내분비학회 / 1999 / 내분비학 / 고려의학 :299~310
Yen, P.M / 2001 / Physiological and molecular basis of thyroid hormone action / Physiol Rev 81(3):1097~1142
Fauci, Braunwald / 2008 / Harrison's principles of internal medicine. 17th ed / McGraw-Hill Medica :2230~2231
Surks, M.I. / 2004 / Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management / JAMA 291(2):228~238
대한내분비학회 / 1999 / 내분비학 / 고려의학 :299~310
Yen, P.M / 2001 / Physiological and molecular basis of thyroid hormone action / Physiol Rev 81(3):1097~1142
Fauci, Braunwald / 2008 / Harrison's principles of internal medicine. 17th ed / McGraw-Hill Medica :2230~2231
Surks, M.I. / 2004 / Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management / JAMA 291(2):228~238
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