개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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AMPA receptor (AMPAR)s are heterotetrameric structures made up from 4 units (GluR1-4) and are thought to underlie perception of persistent inflammatory pain. Complete Freund’s adjuvant (CFA)-evoked inflammation induces synaptic GluR2 internalization, which is initiated by GluR2 phosphorylation, in dorsal horn neurons during the maintenance of CFA-induced hypersensitivity. The present study investigated whether electroacupuncture (EA) stimulation has any effect on GluR2 trafficking by using immunoblot and immunohistochemistry. We examined that CFA-induced dorsal horn GluR2 internalization was attenuated by EA treatment. EA treatment could also decrease the level of pGluR2 regardless of whether CFA injection was administrated or not. In addition, previous studies suggest that microglial cells are increased without morphological change in CFA injected animal. In our study, increases in microglial cells in CFA group were observed, whereas EA with or without CFA-injected group showed similar aspects with normal group. In conclusion, our results indicate that EA might blunt CFA-evoked inflammation by coordinating mechanisms at the upstream step of neuron activation and GluR2 phosphorylation.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Zhi-Qi Zhao / 2008 / Neural mechanism underlying acupuncture analgesia / Progress in Neurobiology 85 : 355 ~ 375
2. [학술지(정기간행물)] - Galan, A. / 2002 / Activation of spinal extracellular signaling-regulated kinase-1 and -2 by intraplantar carrageenan in rodents / Neuroscience letters 322 : 37 ~ 40
3. [학술지(정기간행물)] - Ji, R.R. / 1999 / nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity / Nature neuroscience 2 : 1114 ~ 1119
4. [학술지(정기간행물)] - Adwanikar, H. / 2004 / Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation / pain 111 : 125 ~ 135
5. [학술지(정기간행물)] - Kawasaki, Y. / 2004 / Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization / The Journal of neuroscience 24 : 8310 ~ 8321
2. [학술지(정기간행물)] - Galan, A. / 2002 / Activation of spinal extracellular signaling-regulated kinase-1 and -2 by intraplantar carrageenan in rodents / Neuroscience letters 322 : 37 ~ 40
3. [학술지(정기간행물)] - Ji, R.R. / 1999 / nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity / Nature neuroscience 2 : 1114 ~ 1119
4. [학술지(정기간행물)] - Adwanikar, H. / 2004 / Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation / pain 111 : 125 ~ 135
5. [학술지(정기간행물)] - Kawasaki, Y. / 2004 / Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization / The Journal of neuroscience 24 : 8310 ~ 8321
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UCI(KEPA) : I410-ECN-0101-2015-510-001213970