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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Clove has been frequently used as anti-diabetic, anti-microbial, anti-inflammatory, anesthetic drug and remedies for stomachache by coldness. In this study, the antioxidant activity of extract from Clove was studied in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on Cu<SUP>2+</SUP>-induced human LDL oxidation. Anti-platelet aggregation and anti-thrombotic effects of Clove extracts were studied ex vivo methods by mesuring the inhibitory effect on thrombin induced platelet aggregation and the fibrinolytic activity. The Clove extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation in vitro. Moreover Clove extracts were exhibited remarkable inhibitory effect on platelet aggregation and fibrinolytic activity. In conclusion, the Clove extracts have anti-oxidative and anti-atherosclerotic effects in vitro and ex vivo system, which can be used for developing pharmaceutical drug against oxidative stress and atherosclerosis.
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참고문헌 (56)
참고문헌 신청
2009년 사망원인 통계 결과 / 통계청
Vranova, E. / 2002 / Signal transduction during oxidative stress / J Exp Bot 53(372):1227~1236
Finkel, T. / 2000 / Oxidants, oxidative stress and the biology of ageing / Nature 408(6809):239~247
Sies, H / 1991 / Oxidative stress: from basic research to clinical application / Am J Med 30:31S~38S
Wolberg, A.S. / 2008 / Thrombin generation, fibrin clot formation and hemostasis / Transfus Apher Sci 38(1):15~23
Vranova, E. / 2002 / Signal transduction during oxidative stress / J Exp Bot 53(372):1227~1236
Finkel, T. / 2000 / Oxidants, oxidative stress and the biology of ageing / Nature 408(6809):239~247
Sies, H / 1991 / Oxidative stress: from basic research to clinical application / Am J Med 30:31S~38S
Wolberg, A.S. / 2008 / Thrombin generation, fibrin clot formation and hemostasis / Transfus Apher Sci 38(1):15~23
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