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논문 기본 정보

자료유형
학술저널
저자정보
Hyun Soo Shim (The Catholic University) Hyun Jung Park (The Catholic University) Kyung Soo Kim (The Catholic University) Dae Hyun Hahm (Kyung Hee University) Hye Jung Lee (Kyung Hee University) Insop Shim (Kyung Hee University)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제24권 제2호
발행연도
2010.4
수록면
328 - 332 (5page)

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초록· 키워드

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Acupuncture has been used for the treatment and prevention of stress-related disorders. In the present study, the effect of electroacupuncture on the behavioral and biochemical responses to restraint stress was evaluated in rats. Sprague-Dawley male rats underwent to immobilization stress for 21 days (6 hours/day). Electroacupuncture (2 Hz, 2 mA, and 10 minutes) was applied either to the acupuncture point HT7 (Shenmen) or the nonacupuncture point in the tail for the last 7 days. Rats were randomly divided into four groups: the normal group (n=10, without the restraint stress), the stress group (n=10, with restraint stress), the HT7 group (n=10, with restraint stress and electroacupuncture to HT7), and the NA group (n=10, with restraint stress and electroacupuncture to the nonacupuncture point). The anxiety-related behavior was tested using the elevated plus maze and the Vogel test on day 22. The expression of tyrosine hydroxylase in the locus coeruleus was measured by immunohistochemistry. R maze and the Vogecreased the response of the anxiety-related behavior. The number of tyrosine hydroxylase-immunoreactive cells were also increased. The HT7 group showed a significant decrease of anxiety-related behavioral response, compared to the stress group. The tyrosine hydroxylase-immunoreactive expression was also decreased in the HT7 group. These findings suggestthat electroacupuncture to HT7 might play a role in reducing the stress-related responses, which may be helpful for the treatment of stress-related disorders.

목차

Introduction
Materials and Methods
Results
Discussion
References

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