지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 874 - 885 (12page)
이용수
초록· 키워드
오류제보하기
In the present study, the possibility of whether the pharmacological effects of Scutellariae Radix Aqueous Extracts(SR) were favorably changed by report that lipopolysaccharide(LPS)-induced rat acute lung injury was treated with Red-Koji(Monascus purpureus 12002) fermentation. Three different dosages of Red-Koji fermented SR extract(fSR), 125, 250 and 500 mg/kg were orally administered once a day for 28 days before LPS(Escherichia coli 0111:B4) treatments, and then 5 hours after LPS treatment(500 μg/head, intra trachea instillation), all rats were sacrificed. Changes in the body weights, lung weights, pulmonary transcapillary albumin transit, arterial gas parameters(pH, PaO2 and PaCO2) bronchoalveolar lavage fluid(BALF) protein, lactate dehydrogenase(LDH) and proinflammatory cytokine tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β) contents, total cell numbers, neutrophil and alveolar macrophage ratios, lung malondialdehyde(MDA), myeloperoxidase(MPO), proinflammatory cytokine TNF-α and IL-1βcontents were observed with histopathology of the lung, changes on luminal surface of alveolus(LSA), thickness of alveolar septum, number of polymorphonuclear neutrophils(PMNs). As results of LPS-injection, dramatical increases in lung weights, pulmonary transcapillary albumin transit increases in PaCO2, decreases in pH of arterial blood and PaO2, increases of BALF protein, LDH, TNF-α and IL-1β contents, total cells, neutrophil and alveolar macrophage ratios, lung MDA, MPO, TNF-α and IL-1β contents increases were detected with decreases in LSA and increases of alveolar septum and PMNs numbers, respectively as compared with intact control. Especially fSR 125 mg/kg showed quite similar favorable effects on the LPS-induced acute lung injuries as compared with 60 mg/kg of α-lipoic acid and 250 mg/kg of SR. The results suggest that over 125 mg/kg of fSR extracts showed favorable effects on the LPS-induced acute lung injury mediated by their antioxidant and anti-inflammatory effects. Moreover, increases of the pharmacological effects of SR on LPS-induced acute lung injury were observed by Red-Koji fermentation in this study, at least 2-fold higher.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - 박정현 / 2009 / 비만에서 장내 미생물 균총의 역할과 발효 한약의 활용 / 한방비만학회지 9 (1) : 1 ~ 14
2. [학술지(정기간행물)] - Endo, A. / 1979 / a new hypocholesterolemic agent produced by Monascus species / J Antibiot 32 (8) : 852 ~ 854
3. [학술지(정기간행물)] - 차재영 / 2009 / 홍국발효홍삼 분말 급여에 의한 흰쥐의 혈청 지질 농도 및 항산화 활성에 미치는 영향 / 한국식품영양과학회지 38 (9) : 1153 ~ 1160
4. [단행본] - 한의과대학 본초학 편찬위원회 / 2004 / 본초학 / 영림사 : 218 ~ 219
5. [학술지(정기간행물)] - McManus, L. M. / 1985 / Kinetics of acetyl glyceryl ether phosphorylcholine(AGEPC)-induced acute lung alterations in the rabbit / Am J Pathol 121 (1) : 55 ~ 68
2. [학술지(정기간행물)] - Endo, A. / 1979 / a new hypocholesterolemic agent produced by Monascus species / J Antibiot 32 (8) : 852 ~ 854
3. [학술지(정기간행물)] - 차재영 / 2009 / 홍국발효홍삼 분말 급여에 의한 흰쥐의 혈청 지질 농도 및 항산화 활성에 미치는 영향 / 한국식품영양과학회지 38 (9) : 1153 ~ 1160
4. [단행본] - 한의과대학 본초학 편찬위원회 / 2004 / 본초학 / 영림사 : 218 ~ 219
5. [학술지(정기간행물)] - McManus, L. M. / 1985 / Kinetics of acetyl glyceryl ether phosphorylcholine(AGEPC)-induced acute lung alterations in the rabbit / Am J Pathol 121 (1) : 55 ~ 68
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet
Mi Joung Kim
,
Jeong Ohn
,
Jung Hee Kim
외 1명
Nutrition Research and Practice
2011
.10
복분자 추출물이 Lipopolysaccharide로 유도된 간 손상에 대한 항산화 효과
김인덕
,
강금석
,
권륜희
외 1명
Toxicological Research
2007
.12
Lipopolysaccharide와 어성초 혼합 추출물의 지질대사 상관성
권륜희
,
강금석
,
김인덕
외 1명
Toxicological Research
2007
.12
Differential Expression of Chemokine MCP-1, MIP-1α, MIP-2 in Lipopolysaccharide-stimulated Neonatal and Adult Rat Brain
Jong-hwan Lee
생명과학회지
2006
.08
최근 본 자료
댓글(0)
0