지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Atopic dermatitis (AD) is an inflammatory, relapsing, chronic skin disease and lesions in AD are frequently colonized with Staphylococcus aureus (S. aureus). Activation of T cells and IgE production by staphylococcal enterotoxins B (SEB) plays a crucial role in the pathogenesis of AD. Enterococcus faecalis (E. faecalis) is a nonpathogenic bacterium and produces the probiotic products that have been shown to have inhibitory effects on inflammatory responses. In present study, we carried out to assess the anti-inflammatory role of lyzed E. faecalis against the damaging effects of SEB on AD related immune responses. Furthermore, we attempted to determine whether the co-cultured lyzed E. faecalis can influence the colonization of S. aureus. As a result, we identified the effect of E. faecalis lysate as a potent therapeutic agent for atopic dermatitis (AD). E. faecalis lysate reduces the productions of total IgE and cytokines of AD-related immune cells in response to SEB stimulation. The proliferation of S. aureus was also inhibited by E. faecalis lysate. n conclusions, E. faecalis lysate may improve the skin-defense system disturbed by atopic condition, and may prevent subsequent secondary infection of S. aureus and development of AD.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Baker BS / 2006 / The role of microorganisms in atopic dermatitis / Clin Exp Immunol 144 : 1 ~ 9
2. [학술지(정기간행물)] - Boguniewicz M / 2011 / Atopic dermatitis: a disease of altered skin barrier and immune dysregulation / Immunol Rev 242 : 233 ~ 246
3. [학술지(정기간행물)] - Brosnahan AJ / 2013 / Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids / PLOS One 8 : e61255 ~
4. [학술지(정기간행물)] - Harris LG / 2002 / An introduction to Staphylococcus aureus, and techniques for indentifying and quantifying S. aureus adhesions in relation to adhesion to biomaterials: review / Eur Cell Mater 4 : 39 ~ 60
5. [학술지(정기간행물)] - Guzik TJ / 2005 / Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters / Clin Exp Allergy 35 : 448 ~ 455
2. [학술지(정기간행물)] - Boguniewicz M / 2011 / Atopic dermatitis: a disease of altered skin barrier and immune dysregulation / Immunol Rev 242 : 233 ~ 246
3. [학술지(정기간행물)] - Brosnahan AJ / 2013 / Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids / PLOS One 8 : e61255 ~
4. [학술지(정기간행물)] - Harris LG / 2002 / An introduction to Staphylococcus aureus, and techniques for indentifying and quantifying S. aureus adhesions in relation to adhesion to biomaterials: review / Eur Cell Mater 4 : 39 ~ 60
5. [학술지(정기간행물)] - Guzik TJ / 2005 / Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters / Clin Exp Allergy 35 : 448 ~ 455
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2015-500-001321424