지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Zinc, one of the trace elements which involved in various biological processes in oocytes including meiotic resumption, metaphase arrest, oocytes activation. Meiotic progress in mammalian oocytes regulate by serial mechanism. Meiotic promote factor is the principle molecular involving the process. Activity of MPF is regulated by EMI2, a zinc dependent protein, which release APC/C in the absence of zinc. Released APC/C resulted ubiquitinized of MPF, further regulate the process of division. In addition, protein kinase C, which regulated by zinc, also play important role in meiotic resumption. An inter-regulation were fund between PKC and zinc. Depletion of zinc reduced activity of PKC, however, activation of PKC release free zinc into cytoplasm, confirmed the activity of MPF. Therefore, in this review, we provide a new insight of role of zinc in meiotic progression of mammalian oocyte.
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ABSTRACT
Introduction
Meiotic division
MPF and MAPK in maturation
Relationship of PKC and oocytes maturation
Function of zinc in meiotic division
Relationship between zinc and MPF metabolism
Relationship between zinc and PKC
Conclusion
Reference
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UCI(KEPA) : I410-ECN-0101-2015-490-001685788