지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 64 - 67 (4page)
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초록· 키워드
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Background: The purpose of this study was to determine whether in patients with rotator cuff tears a correlation exists between molecular changes and clinical parameters such as age, duration of symptom, range of motion, and tear size. Molecular changes of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) were assessed by measuring messenger RNA (mRNA) levels of the two proteins.
Methods: The rotator cuff tissue from was obtained from the edge of a torn tendon revealed after debridement by a motorized shaver. Using the sample of rotator cuff tissue, the reverse transcription polymerase chain reaction was performed to quantify MMP-2 and TIMP-2 mRNA expression. To determine whether mRNA levels and the clinical variables, such as age, defect size, range of motion (ROM) of shoulder, and duration of symptoms, show any correlation, Spearman’s correlation coefficients were used to test for significant differences.
Results: There was an inverse correlation between the mRNA levels of MMP-2 and TIMP-2 from the torn rotator cuff tendons regardless of the clinical variables. However, comparison of mRNA levels versus clinical parameters such as age, defect size, range of motion and duration of symptoms revealed a number of findings. We found a significant correlation between age and mRNA levels of MMP-2 from torn cuffs (r = 0.513, p = 0.021). Further, we found a significant correlation between defect size in the full thickness tears and mRNA levels of MMP-2 (r = 0.454, p = 0.045). Conversely, no significant association between mRNA levels of MMP-2 and ROM or duration of symptom was found.
Conclusions: Our results suggest that both MMP-2 and TIMP-2 may be involved in the disease process of rotator cuff tears. Although the level of mRNA expression of MMP-2 and TMP-2 remain constant in torn rotator cuffs irrespective of the clinical variables, their levels may be influenced by age and defect size, which could account to change in tendon degradation and the healing process.
Methods: The rotator cuff tissue from was obtained from the edge of a torn tendon revealed after debridement by a motorized shaver. Using the sample of rotator cuff tissue, the reverse transcription polymerase chain reaction was performed to quantify MMP-2 and TIMP-2 mRNA expression. To determine whether mRNA levels and the clinical variables, such as age, defect size, range of motion (ROM) of shoulder, and duration of symptoms, show any correlation, Spearman’s correlation coefficients were used to test for significant differences.
Results: There was an inverse correlation between the mRNA levels of MMP-2 and TIMP-2 from the torn rotator cuff tendons regardless of the clinical variables. However, comparison of mRNA levels versus clinical parameters such as age, defect size, range of motion and duration of symptoms revealed a number of findings. We found a significant correlation between age and mRNA levels of MMP-2 from torn cuffs (r = 0.513, p = 0.021). Further, we found a significant correlation between defect size in the full thickness tears and mRNA levels of MMP-2 (r = 0.454, p = 0.045). Conversely, no significant association between mRNA levels of MMP-2 and ROM or duration of symptom was found.
Conclusions: Our results suggest that both MMP-2 and TIMP-2 may be involved in the disease process of rotator cuff tears. Although the level of mRNA expression of MMP-2 and TMP-2 remain constant in torn rotator cuffs irrespective of the clinical variables, their levels may be influenced by age and defect size, which could account to change in tendon degradation and the healing process.
목차
Introduction
Methods
Results
Discussion
References
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Murrell GA / 2001 / Diagnosis of rotator cuff tears / Lancet 357 (9258) : 769 ~ 770
2. [학술지(정기간행물)] - Cofield RH / 2001 / Surgical repair of chronic rotator cuff tears. A prospective long-term study / J Bone Joint Surg Am 83-A (1) : 71 ~ 77
3. [학술지(정기간행물)] - Hattrup SJ / 1995 / Rotator cuff repair : relevance of patient age / J Shoulder Elbow Surg 4 (2) : 95 ~ 100
4. [학술지(정기간행물)] - Jensen KL / 1999 / Rotator cuff tear arthropathy / J Bone Joint Surg Am 81 (9) : 1312 ~ 1324
5. [학술지(정기간행물)] - Tetlow LC / 2001 / Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage : associations with degenerative changes / Arthritis Rheum 44 (3) : 585 ~ 594
2. [학술지(정기간행물)] - Cofield RH / 2001 / Surgical repair of chronic rotator cuff tears. A prospective long-term study / J Bone Joint Surg Am 83-A (1) : 71 ~ 77
3. [학술지(정기간행물)] - Hattrup SJ / 1995 / Rotator cuff repair : relevance of patient age / J Shoulder Elbow Surg 4 (2) : 95 ~ 100
4. [학술지(정기간행물)] - Jensen KL / 1999 / Rotator cuff tear arthropathy / J Bone Joint Surg Am 81 (9) : 1312 ~ 1324
5. [학술지(정기간행물)] - Tetlow LC / 2001 / Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage : associations with degenerative changes / Arthritis Rheum 44 (3) : 585 ~ 594
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UCI(KEPA) : I410-ECN-0101-2015-510-002538512