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논문 기본 정보

자료유형
학술저널
저자정보
(Daejeon University)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제20권 제3호
발행연도
수록면
124 - 128 (5page)

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초록· 키워드

Alcoholism is a significant global health problem. Alcohol dehydrogenase and aldehyde dehydrogenase play important roles in the metabolism of alcohol and aldehyde. In this study, we aimed to investigate the eliminatory effects of a fruit extract drink on alcohol metabolism in drunken Sprague-Dawley (SD) rats. Male SD rats were given a fruit extract drink or a commercial product (10 mL/kg) 30 min prior to 40% (5 g/kg) ethanol ingestion. To assay the effect of the fruit extract drink on blood ethanol concentration, blood samples were taken from the saphenous vein at 3 and 5 h after ethanol ingestion. The blood concentrations of alcohol, alcohol dehydrogenase, and aldehyde dehydrogenase were significantly lower in the fruit extract drink group than in the control group, in a time-dependent manner. However, the alanine aminotransferase and aspartate aminotransferase activities of all experimental groups were unaltered compared to those of the control group. These results suggested that fruit extract drink intake can have a positive effect on the reduction of alcohol, alcohol dehydrogenase, and aldehyde dehydrogenase concentrations in the blood and may alleviate acute ethanol-induced hepatotoxicity by altering alcohol metabolic enzyme activities.
#Alcoholism #Fruit extract #Alcohol dehydrogenase #Aldehyde dehydrogenase #Liver injury
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목차

  1. INTRODUCTION
  2. MATERIALS AND METHODS
  3. RESULTS
  4. DISCUSSION
  5. REFERENCES

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