지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 143 - 150 (8page)
이용수
초록· 키워드
오류제보하기
Genistein is one of isoflavones mostly derived in a leguminous plant. It is well known as one of phytoestrogens that have structures similar to the principal mammalian estrogen. It has diverse biological functions including chemopreventive properties against cancers. Anticancer efficacies of genistein have been related with the epidemiological observations indicating that the incidence of some cancers is much lower in Asia, where diets are rich in soyfoods, than Western countries. This review deals with in vivo anticancer activities of genistein identified in animal studies being divided into its effects on carcinogenesis and cancer progression. Because animal studies have advantages in designing the experiments to suit the goals, they imply diverse information on the anticancer activity of genistein. The in vivo animal studies have adopted the specific animal models according to a developmental stage of cancer to prove the anticancer efficacies of genistein against diverse types of cancer. The numerous previous studies insist that genistein effectively inhibits carcinogenesis in the DMBA-induced animal cancer models by reducing the incidence of adenocarcinoma and cancer progression in the transgenic and xenograft animal models by suppressing the tumor growth and metastatic transition. Although the protective effect of genistein against cancer has been controversial, genistein may be a candidate for chemoprevention of carcinogenesis and cancer progression and may deserve to be the central compound supporting the epidemiological evidence.
목차
Anticancer Activities of Genistein on Carcinogenesis
Anticancer Activities of Genistein on Cancer Progression
Conclusion
References
참고문헌 (84)
참고문헌 신청
1. [학술지(정기간행물)] - Adjakly M. / 2013 / Genistein and daidzein : different molecular effects on prostate cancer / Anticancer Res 33 (1) : 39 ~ 44
2. [학술지(정기간행물)] - Adlercreutz H. / 1995 / Phytoestrogens: epidemiology and a possible role in cancer protection / Environ Health Perspect 103 (Suppl 7) : 103 ~ 112
3. [학술지(정기간행물)] - Ahmad A. / 2013 / Perspectives on the role of isoflavones in prostate cancer / AAPS J 15 (4) : 991 ~ 1000
4. [학술지(정기간행물)] - Aidoo A. / 2005 / Effects of daidzein, genistein, and 17betaestradiol on 7, 12-dimethylbenz[a]anthracene-induced mutagenicity and uterine dysplasia in ovariectomized rats / Nutr Cancer 53 (1) : 82 ~ 90
5. [학술지(정기간행물)] - Behloul N. / 2013 / Genistein: a promising therapeutic agent for obesity and diabetes treatment / Eur J Pharmacol 698 (1-3) : 31 ~ 38
2. [학술지(정기간행물)] - Adlercreutz H. / 1995 / Phytoestrogens: epidemiology and a possible role in cancer protection / Environ Health Perspect 103 (Suppl 7) : 103 ~ 112
3. [학술지(정기간행물)] - Ahmad A. / 2013 / Perspectives on the role of isoflavones in prostate cancer / AAPS J 15 (4) : 991 ~ 1000
4. [학술지(정기간행물)] - Aidoo A. / 2005 / Effects of daidzein, genistein, and 17betaestradiol on 7, 12-dimethylbenz[a]anthracene-induced mutagenicity and uterine dysplasia in ovariectomized rats / Nutr Cancer 53 (1) : 82 ~ 90
5. [학술지(정기간행물)] - Behloul N. / 2013 / Genistein: a promising therapeutic agent for obesity and diabetes treatment / Eur J Pharmacol 698 (1-3) : 31 ~ 38
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UCI(KEPA) : I410-ECN-0101-2016-528-001001794