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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 174 - 180 (7page)
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We investigated the protective effects of pine bark extract (pycnogenol<SUP>®</SUP>, PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1) vehicle control, (2) cisplatin (7.5 mg/kg), (3) cisplatin & PYC 10 (10 mg/kg/day), and (4) cisplatin & PYC 20 (20 mg/kg/day). A single intraperitoneal injection of cisplatin induced hepatotoxicity, as evidenced by an increase in serum aminotransferase and histopathological alterations, including degeneration/necrosis of hepatocytes, vacuolation, and sinusoidal dilation. In addition, an increase in the malondialdehyde (MDA) concentration and a decrease in the reduced glutathione (GSH) content and catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities were observed in the cisplatin-treated rat hepatic tissues. In contrast, PYC treatment effectively prevented cisplatin-induced hepatotoxicity, including the elevation of aminotransferase and histopathological lesions, in a dosedependent manner. Moreover, PYC treatment also induced antioxidant activity by decreasing MDA level and increasing GSH content and SOD and GST activities in liver tissues. These results indicate that PYC has a protective effect against acute hepatotoxicity induced by cisplatin in rats, and that the protective effects of PYC may be due to inhibiting lipid peroxidation and increasing antioxidant activity.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Wiltshaw, E. / 1976 / Phase two study of cis-dichlorodimmine-platinum(II)in advanced adenocarcinoma of the ovary / Cancer Treat Rep 60 : 55 ~ 60
2. [학술지(정기간행물)] - Jordan P. / 2000 / Molecular mechanisms involved in cisplatin cytotoxicity / Cell Mol Life Sci 57 : 1229 ~ 1235
3. [학술지(정기간행물)] - Crown JP. / 2001 / The platinum agents : a role in breast cancer treatment? / Semin Oncol 28 : 28 ~ 37
4. [단행본] - Pinedo, H. M. / 1996 / Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy / Plenum
5. [학술지(정기간행물)] - Yang D. / 1996 / Structural studies of interactions between anticancer platinum drugs and DNA / Prog Biophys Mol Biol 66 (1) : 81 ~ 111
2. [학술지(정기간행물)] - Jordan P. / 2000 / Molecular mechanisms involved in cisplatin cytotoxicity / Cell Mol Life Sci 57 : 1229 ~ 1235
3. [학술지(정기간행물)] - Crown JP. / 2001 / The platinum agents : a role in breast cancer treatment? / Semin Oncol 28 : 28 ~ 37
4. [단행본] - Pinedo, H. M. / 1996 / Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy / Plenum
5. [학술지(정기간행물)] - Yang D. / 1996 / Structural studies of interactions between anticancer platinum drugs and DNA / Prog Biophys Mol Biol 66 (1) : 81 ~ 111
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UCI(KEPA) : I410-ECN-0101-2016-528-001001830