지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 251 - 260 (10page)
이용수
초록· 키워드
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The number of farmers who have suffered from non-fatal acute pesticide poisoning has been reported to vary from 5.7% to 86.7% in South Korea since 1975. Absorption through the skin is the main route of exposure to pesticides for farmers who operate with them. Several in vitro tests using the skins of humans or animal and in vivo tests using laboratory animals are introduced for the assessment of human dermal absorption level of pesticides. The objective of this study is to evaluate and compare international guidelines and strategies of dermal absorption assessments and to propose unique approaches for applications into pesticide registration process in our situation. Until present in our situation, pesticide exposure level to operator is determined just using default value of 10 as for skin absorption ratio because of data shortage. Dermal absorption tests are requested to get exposure level of pesticides and to ultimately know the safety of pesticides for operators through the comparison with the value of AOEL. When the exposure level is higher than AOEL, the pesticide cannot be approved. We reviewed the skin absorption test guidelines recommended by OECD, EFSA and EPA. The EPA recommends assessment of skin absorption of pesticides for humans through the TPA which includes all the results of in vitro human and animal and animal in vivo skin absorption studies. OECD and EFSA, employ a tiered approach, which the requirement of further study depends on the results of the former stage study. OECD guidelines accept the analysis of pesticide level absorbed through skin without radioisotope when the recovery using the non-labeled method is within 80~120%. Various factors are reviewed in this study, including the origin of skin (gender, animal species and sites of skin), thickness, temperature and, etc., which can influence the integrity of results.
목차
INTRODUCTION
PERSPECTIVES
REFERENCES
참고문헌 (28)
참고문헌 신청
Cole, D. C. / 2000 / Economic burden of illness from pesticide poisonings in highland Ecuador / Rev. Panam. Salud Publica 8:196~201
Wesseling, C. / 1993 / Pesticide poisonings in Costa Rica / Scand J. Work Environ. Health 19:227~235
Corriols, M. / 2009 / Incidence of acute pesticide poisonings in Nicaragua: a public health concern / Occup. Environ. Med 66:205~210
Lee, W. J. / 2012 / Incidence of acute occupational pesticide poisoning among male farmers in South Korea / Am. J. Ind. Med 55:799~807
Benford, D. J. / 1999 / Dermal route in systemic exposure / Scand J. Work Environ. Health 25:511~520
Wesseling, C. / 1993 / Pesticide poisonings in Costa Rica / Scand J. Work Environ. Health 19:227~235
Corriols, M. / 2009 / Incidence of acute pesticide poisonings in Nicaragua: a public health concern / Occup. Environ. Med 66:205~210
Lee, W. J. / 2012 / Incidence of acute occupational pesticide poisoning among male farmers in South Korea / Am. J. Ind. Med 55:799~807
Benford, D. J. / 1999 / Dermal route in systemic exposure / Scand J. Work Environ. Health 25:511~520
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UCI(KEPA) : I410-ECN-0101-2016-513-001047860