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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 169 - 177 (9page)
- DOI
- 10.15188/kjopp.2014.04.28.2.169
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초록· 키워드
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This study aimed to investigate the relaxation effects and its underlying mechanisms of Epimedium koreanum Nakai(EK) in phenylephrine(PE) treated isolated rabbit corpus cavernosum smooth muscle. The dose-dependent relaxation responses of phenylephrine(PE, 1×10<SUP>-6</SUP> M)-precontracted strips to EK at 0.01-3.0 ㎎/㎖ were measured and also observed after endothelial denudation using organ bath. To analyze the underlying mechanisms of EK-induced relaxation, Nω-nitro-L-arginine(L-NNA), methylene blue(MB), tetraethylammonium chloride(TEA), indomethacin(IM) were pretreated before EK extract infused into precontracted strips induced by PE. To investigate cytotoxic activity and nitric oxide(NO) concentration of EK extract on EA.hy926 cells, mitochondrial dehydrogenase activity(MTT) assay and nitric oxide detection kit were used. The cavernous strips were significantly relaxed by EK extract at 0.3 ㎎/㎖, 1.0 ㎎/㎖, 3.0 ㎎/㎖ and the relaxation responses of PE-precontracted strips denuded endothelium also inhibited in comparison with intact endothelium. The pretreatment of L-NNA, MB, TEA reduced EK extract-induced endothelium-dependent relaxation, but the pretreatment of IM didn"t affect EK extract-induced endothelium-dependent relaxation. When EK extract was applicated on EA.hy926 cells, the NO concentration was increased. Our findings have shown that EK extract exerts a relaxing effect on corpus cavernosum in part by suppressing influx of extracellular Ca<SUP>2+</SUP> through activating the NO-cGMP system.
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References
참고문헌 (57)
참고문헌 신청
1. [학술지(정기간행물)] - Kim, Y.S. / 2000 / Prevalence and screening of male sexual dysfunction in family medicine clinic / J Korean Acad Fam Med 21 : 62 ~ 73
2. [인터넷자원] - 식품의약품안전처 / / 경구용 발기부전 치료제
3. [단행본] - 신민교 / 1992 / 원색임상본초학 / 영림사 : 196 ~ 197
4. [단행본] - 江蘇新醫學阮 / 1998 / 중약대사전 / 정담 : 4400 ~ 4406
5. [단행본] - Huang, K.C. / 1993 / The pharamacology of Chines herbs / CRC Press Inc : 91 ~ 92
2. [인터넷자원] - 식품의약품안전처 / / 경구용 발기부전 치료제
3. [단행본] - 신민교 / 1992 / 원색임상본초학 / 영림사 : 196 ~ 197
4. [단행본] - 江蘇新醫學阮 / 1998 / 중약대사전 / 정담 : 4400 ~ 4406
5. [단행본] - Huang, K.C. / 1993 / The pharamacology of Chines herbs / CRC Press Inc : 91 ~ 92
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UCI(KEPA) : I410-ECN-0101-2016-519-000932002