지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 263 - 272 (10page)
- DOI
- 10.14815/kjdm.2014.41.4.263
이용수
초록· 키워드
오류제보하기
The purposes of this study were to observe influence of diabetes mellitus(DM) on the expression of MMP?3 of stromelysin type and MMP?14 of membrane type matrix metalloproteinase in the gingival tissues of patients with type 2 DM and healthy adults with chronic periodontitis. Gingival samples were devided into three groups. Group 1 is clinically healthy gingiva without bleeding, bone resorption or periodontal pockets. Group 2 is inflammed gingiva from patients with chronic periodontitis. Group 3 is inflammed gingiva from patients with chronic periodontitis associated with type 2 DM. Tissue samples were analyzed by Western blotting. The quantification of MMP?3 and MMP?14 were performed using a densitometer. MMP?3 and MMP?14 expressions were similar in group 1 and 2. While expression of MMP-14 increases in proportion to MMP-3 expression, expression of both type of MMP showed increasing tendency in chronic periodontitis associated to type 2 DM and mean amount of it was more increased in group 3 comparing to other group with statistically significant difference.
In conclusion, MMP?3 and MMP?14 expression levels were similar in healthy and inflamed gingival tissue from systemically healthy patients. And tissue with chronic periodontitis associated to type 2 DM showed significantly increased MMP?3 and MMP?14 levels compared to healthy and non?diabetic inflamed gingiva. Also, MMP?3 may be related to MMP?14 activity in chronic periodontitis associated with type 2 DM. Therefore, the expression levels of MMP?3 and MMP?14 will be inflammatory markers of periodontal inflammed tissue with type 2 DM.
In conclusion, MMP?3 and MMP?14 expression levels were similar in healthy and inflamed gingival tissue from systemically healthy patients. And tissue with chronic periodontitis associated to type 2 DM showed significantly increased MMP?3 and MMP?14 levels compared to healthy and non?diabetic inflamed gingiva. Also, MMP?3 may be related to MMP?14 activity in chronic periodontitis associated with type 2 DM. Therefore, the expression levels of MMP?3 and MMP?14 will be inflammatory markers of periodontal inflammed tissue with type 2 DM.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (54)
참고문헌 신청
1. [학술지(정기간행물)] - Achong R / 2003 / Membrane Type(MT)1-matrix metalloproteinase(MMP)and MMP-2 expression in ligature-induced periodontitis in the rat / J Periodont 74 : 494 ~ 500
2. [학술지(정기간행물)] - Amitage GC / 1999 / Development of a classification system for periodontal diseases and conditions / Ann Periodontol 4 : 1 ~ 6
3. [학술지(정기간행물)] - Arza B / 2000 / Prostromelysin-1(proMMP-3)stimulates plasminogen activation by tissue-type plasminogen activator / Eur J Biochem 267 : 6378 ~ 6384
4. [학술지(정기간행물)] - Beklen A / 2006 / Gingival tissue and crevicular fluid co-operation in adult periodontitis / J Dental Res 85 (1) : 59 ~ 63
5. [학술지(정기간행물)] - Bissada NF / 1982 / Neutrophil functional activity in juvenile and adult onset diabetic patients with mild and severe periodontitis / J Periodontal Res 17 : 500 ~ 502
2. [학술지(정기간행물)] - Amitage GC / 1999 / Development of a classification system for periodontal diseases and conditions / Ann Periodontol 4 : 1 ~ 6
3. [학술지(정기간행물)] - Arza B / 2000 / Prostromelysin-1(proMMP-3)stimulates plasminogen activation by tissue-type plasminogen activator / Eur J Biochem 267 : 6378 ~ 6384
4. [학술지(정기간행물)] - Beklen A / 2006 / Gingival tissue and crevicular fluid co-operation in adult periodontitis / J Dental Res 85 (1) : 59 ~ 63
5. [학술지(정기간행물)] - Bissada NF / 1982 / Neutrophil functional activity in juvenile and adult onset diabetic patients with mild and severe periodontitis / J Periodontal Res 17 : 500 ~ 502
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UCI(KEPA) : I410-ECN-0101-2016-515-000941023