지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Polymersomes made of biodegradable triblock copolymers based on poly(fumaric acid-co-sebacoyl chloride)/ PEG (PEG-co-P(FA/SC)-co-PEG) were prepared and studied in aqueous solutions. TEM confirmed the formation of vesicles in aqueous media. Aggregation behavior of the copolymers was studied by fluorescence spectroscopy of 8-anilino- 1-naphthalenesulfonic acid, and the critical aggregation concentration (c.a.c.) of the copolymer was found to be ~26.2 μM indicating desirable stability of the vesicles. Dynamic light scattering revealed that the size of the vesicles was distributed within the range of 170-270 nm. Turbidity measurements confirmed the relative short-term stability of the polymersomes. Carboxyfluorescein, a hydrophilic compound, was simply encapsulated in the vesicles during polymersome preparation. The release of encapsulant from the polymersomes at 25 and 37 oC lasted about 3 weeks, and the rate of release followed a first-order kinetics. The release is speculated to be primarily carried out through diffusion. These results confirm that these polymersomes are promising as controlled-release carriers of various drugs.
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참고문헌 (55)
참고문헌 신청
1. [학술지(정기간행물)] - P. Bahadur / 2001 / / Curr. Sci 80 : 1002 ~
2. [학술지(정기간행물)] - R. Gref / 1994 / / Science 263 : 1600 ~
3. [학술지(정기간행물)] - K. Kita-Tokarczyk / 2005 / / Polymer 46 : 3540 ~
4. [학술지(정기간행물)] - T. Liu / 2004 / / Polymer 45 : 7989 ~
5. [학술지(정기간행물)] - T. Liu / 1998 / / J. Phys. Chem. B 102 : 2875 ~
2. [학술지(정기간행물)] - R. Gref / 1994 / / Science 263 : 1600 ~
3. [학술지(정기간행물)] - K. Kita-Tokarczyk / 2005 / / Polymer 46 : 3540 ~
4. [학술지(정기간행물)] - T. Liu / 2004 / / Polymer 45 : 7989 ~
5. [학술지(정기간행물)] - T. Liu / 1998 / / J. Phys. Chem. B 102 : 2875 ~
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