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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 87 - 98 (12page)
- DOI
- 10.17495/easdl.2015.2.25.1.87
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We investigated the apoptotic effects of grape skin extracts (GSE) and related gene expressions in human breast cancer MDA-MB-231 cells cultured in the presence of 0, 0.5, 1 and 1.5 mg/mL of GSE for 72 hours. MTT assay, trypan blue and nuclei staining showed lower cellular mitochondrial activities and increased cell deaths with a higher concentration of GSE (p<0.05). Increased cell number with fragmentated DNA of sub-G1 phase was calculated as a measure of apoptotic cell death by FACS analysis (p<0.05). In particular, apoptotic cell death caused markedly increased in the 1 and 1.5 mg/mL of GSE groups, as revealed by flow cytometry (Annexin V-FITC). RT-PCR analysis was performed on apoptotic and preapoptotic genes. Expression of the apoptosis suppressor gene bcl-2 significantly decreased, proapoptotic gene bax was significantly increased and procaspase-3 showing the presence of caspase-3 significantly decreased (p<0.05). Furthermore, bcl-2/bax ratio which is considered to be an important indicator of apoptosis, significantly decreased in a concentration-dependent manner (p<0.05). These results indicated that GSE induces apoptosis in MDA-MB-231 human breast cancer cells.
목차
ABSTRACT
서론
재료 및 방법
결과 및 고찰
결론 및 요약
REFERENCES
참고문헌 (40)
참고문헌 신청
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2. [학술지(정기간행물)] - Aggarwal BB / 2004 / Role of resveratrol in prevention and therapy of cancer : Preclinical and clinical studies / Anticancer Res 24 : 2783 ~ 2840
3. [학술지(정기간행물)] - Benitez DA / 2007 / Mechanisms involved in resveratrol induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines / J Andrology 28 : 282 ~ 293
4. [학술지(정기간행물)] - Bertelli AA / 1998 / Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human promonocytes : A co-factor in antiinflammatory and anticancer chemopreventive activity / Int J Tissue React 21 : 93 ~ 104
5. [학술지(정기간행물)] - 조성민 / 2000 / 내독소로 유도된 임신 생쥐의 태반감염시 태아대뇌에서 관찰되는 Apoptosis와 Bcl-2, Bcl-xs, Bax 발현과의 관계 / Korean Journal of Pediatrics 43 (1) : 97 ~ 104
2. [학술지(정기간행물)] - Aggarwal BB / 2004 / Role of resveratrol in prevention and therapy of cancer : Preclinical and clinical studies / Anticancer Res 24 : 2783 ~ 2840
3. [학술지(정기간행물)] - Benitez DA / 2007 / Mechanisms involved in resveratrol induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines / J Andrology 28 : 282 ~ 293
4. [학술지(정기간행물)] - Bertelli AA / 1998 / Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human promonocytes : A co-factor in antiinflammatory and anticancer chemopreventive activity / Int J Tissue React 21 : 93 ~ 104
5. [학술지(정기간행물)] - 조성민 / 2000 / 내독소로 유도된 임신 생쥐의 태반감염시 태아대뇌에서 관찰되는 Apoptosis와 Bcl-2, Bcl-xs, Bax 발현과의 관계 / Korean Journal of Pediatrics 43 (1) : 97 ~ 104
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UCI(KEPA) : I410-ECN-0101-2016-594-001276751