인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Regulation of cell growth is very important for cellular regeneration and healing process. Many recent studies have focused on discovering the natural or synthetic substances that have the ability to modulate cellular regeneration and growth. The compounds may be useful for developing the strategies to delay cellular senescence or to promote cellular rejuvenation processes. In this study, KSY-PH1, an active compound found in walnuts, was tested for its role as cellular rejuvenating and wound healing agent. We used skin NHDF cells and mouse model to observe their response to deleterious environmental factors such as UVB irradiation and mechanical injury. Specifically, we observed the expressional changes of longevity-related-protein Sirt1 and cell-cycle-related-protein Pin1. It was found that KSY-PH1 positively influence processes like quenching of reactive oxygen species (ROS), cellular growth, wound healing, and cellular apoptosis at least in skin cells because of its unique mechanism of co-regulating Pin1 and Sirt1. Although higher concentrations of KSY-PH1 seemed to reduce cell viability, low concentrations (especially 5μM) promoted regeneration and wound hea ... 전체 초록 보기
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2016-470-001531381