지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 297 - 304 (8page)
이용수
초록· 키워드
오류제보하기
The role of mitogen-activated protein kinases (MAPKs) in regulation of inflammation is well known. MAPK family is activated by various stimuli and involved in transmitting extracellular signals to nucleus leading to gene regulation. Inflammation is primary defensive response of host against microbes. Controlled inflammation is helpful and indispensable for host defense. However, uncontrolled inflammatory response leads to various inflammatory diseases and cancer. Persistent inflammation leads to cell proliferation and survival that plays crucial role in tumorigenesis. In this review, we recapitulate the recent knowledge of MAPK signaling and its roles in inflammation-associated carcinogenesis.
목차
INTRODUCTION
Mitogen-activated Protein Kinases
ERK MAPKs and Cancer Development
JNK MAPKs and Cancer Development
p38 MAPKs and Cancer Development
Inflammation and Caner Development
Conclusion and Perspective
REFERENCES
참고문헌 (76)
참고문헌 신청
1. [학술지(정기간행물)] - Medzhitov R. / 2008 / Origin and physiological roles of inflammation / Nature 454 : 428 ~ 435
2. [학술지(정기간행물)] - Takeuchi O. / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
3. [학술지(정기간행물)] - O'Neill LA. / 2007 / The family of five : TIR-domain-containing adaptors in Toll-like receptor signalling / Nat Rev Immunol 7 : 353 ~ 364
4. [학술지(정기간행물)] - Trinchieri G. / 2007 / Cooperation of Toll-like receptor signals in innate immune defence / Nat Rev Immunol 7 : 179 ~ 190
5. [학술지(정기간행물)] - Miao EA. / 2010 / Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria / Nat Immunol 11 : 1136 ~ 1142
2. [학술지(정기간행물)] - Takeuchi O. / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
3. [학술지(정기간행물)] - O'Neill LA. / 2007 / The family of five : TIR-domain-containing adaptors in Toll-like receptor signalling / Nat Rev Immunol 7 : 353 ~ 364
4. [학술지(정기간행물)] - Trinchieri G. / 2007 / Cooperation of Toll-like receptor signals in innate immune defence / Nat Rev Immunol 7 : 179 ~ 190
5. [학술지(정기간행물)] - Miao EA. / 2010 / Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria / Nat Immunol 11 : 1136 ~ 1142
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