지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 244 - 252 (9page)
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초록· 키워드
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Viruses interact with the host ubiquitination system in a variety of ways. Viral proteins are often a substrate for ubiquitination, which leads to proteasomal degradation. Viruses also have functions to modify the cellular ubiquitination machinery. Recently, deubiquitinating protease (DUB) activity has been found in many viral proteins. In herpesviruses, the DUB domain is found within the large tegument protein, which is conserved in all members of the herpesvirus family. Although a limited number of viral and cellular targets have been identified to date, accumulating evidence shows that herpesviral DUBs may primarily target key cellular regulators of immune signaling pathways to promote viral replication. In this review, we summarize the recent findings on viral DUBs. In particular, we focus on the herpesviral DUBs and their targets, and discuss their potential roles in the regulation of immune signaling pathways.
목차
Introduction
Virus-encoded deubiquitinating proteases
Deubiquitinating proteases encoded by human herpesviruses
Conclusion
REFERENCES
참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Hershko A / 1998 / The ubiquitin system / Annu Rev Biochem 67 : 425 ~ 479
2. [학술지(정기간행물)] - Komander D / 2012 / The ubiquitin code / Annu Rev Biochem 81 : 203 ~ 229
3. [학술지(정기간행물)] - Glickman MH / 2002 / The ubiquitinproteasome proteolytic pathway: destruction for the sake of construction / Physiol Rev 82 : 373 ~ 428
4. [학술지(정기간행물)] - Schnell JD / 2003 / Non-traditional functions of ubiquitin and ubiquitin-binding proteins / J Biol Chem 278 : 35857 ~ 35860
5. [학술지(정기간행물)] - Paludan SR / 2011 / Recognition of herpesviruses by the innate immune system / Nat Rev Immunol 11 : 143 ~ 154
2. [학술지(정기간행물)] - Komander D / 2012 / The ubiquitin code / Annu Rev Biochem 81 : 203 ~ 229
3. [학술지(정기간행물)] - Glickman MH / 2002 / The ubiquitinproteasome proteolytic pathway: destruction for the sake of construction / Physiol Rev 82 : 373 ~ 428
4. [학술지(정기간행물)] - Schnell JD / 2003 / Non-traditional functions of ubiquitin and ubiquitin-binding proteins / J Biol Chem 278 : 35857 ~ 35860
5. [학술지(정기간행물)] - Paludan SR / 2011 / Recognition of herpesviruses by the innate immune system / Nat Rev Immunol 11 : 143 ~ 154
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