지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 297 - 306 (10page)
이용수
초록· 키워드
오류제보하기
p53 is a well-known multi-functional transcription regulator and is critical in the induction of apoptosis in response to various stresses. Human cytomegalovirus (HCMV) infection induced the accumulation of p53, which was partly relocalized in cytoplasm, but no apparent cell death in human fibroblasts. p53 in HCMV-infected cells was mainly mono-ubiquitinated, which might be resulted from the decreased expression of MDM2 in the course of HCMV infection. Ubiquitinated p53 was also phosphorylated at serine 20. CRM1 increased in the cytoplasm of HCMV-infected cells. It was found that p53 and its mutant in nuclear export sequences were localized in the cytoplasm of cells when co-expressed with CRM1. Collectively, our data suggest that HCMV infection modifies p53 into a stable and exportable form and accumulates it in the cytoplasm, but does not result in apoptotic death of cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Moll UM / 1998 / p53--an acrobat in tumorigenesis / Crit Rev Oral Biol Med 9 : 23 ~ 37
2. [학술지(정기간행물)] - Green DR / 2009 / Cytoplasmic functions of the tumour suppressor p53 / Nature 458 : 1127 ~ 1130
3. [학술지(정기간행물)] - Brooks CL / 2004 / Monoubiquitination: the signal for p53 nuclear export? / Cell Cycle 3 : 436 ~ 438
4. [학술지(정기간행물)] - Carter S / 2007 / C-terminal modifications regulate MDM2 dissociation and nuclear export of p53 / Nat Cell Biol 9 : 428 ~ 435
5. [학술지(정기간행물)] - Halaby MJ / 2007 / p53 translational control: a new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics / Gene 395 : 1 ~ 7
2. [학술지(정기간행물)] - Green DR / 2009 / Cytoplasmic functions of the tumour suppressor p53 / Nature 458 : 1127 ~ 1130
3. [학술지(정기간행물)] - Brooks CL / 2004 / Monoubiquitination: the signal for p53 nuclear export? / Cell Cycle 3 : 436 ~ 438
4. [학술지(정기간행물)] - Carter S / 2007 / C-terminal modifications regulate MDM2 dissociation and nuclear export of p53 / Nat Cell Biol 9 : 428 ~ 435
5. [학술지(정기간행물)] - Halaby MJ / 2007 / p53 translational control: a new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics / Gene 395 : 1 ~ 7
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