지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 197 - 205 (9page)
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초록· 키워드
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Group A rotaviruses are a major cause of acute gastroenteritis in young children worldwide. For the proper management of rotavirus infections, knowledge of the distribution of G and P genotypes including detection of emerging genotype is crucial. Therefore, the aim of this study is to describe epidemiological changes in rotavirus gastroenteritis in Gwangju metropolitan city, South Korea. Stool samples were collected from 14,314 patients with diarrhea, who visited hospitals in Gwangju from 2008 to 2012. Samples were screened for rotavirus with Enzyme-Linked Immunosorbent Assay(ELISA) method and rotavirus P (VP4), G (VP7) genotypes were determined by reverse-transcription polymerase chain reaction. And we performed nucleotide sequencing analysis. Among a total of 14,314 samples investigated 1,982 samples (13.8%) were ELISA positive. Genotyping of Rotavirus was performed using 526 rotavirus samples. The most prevalent circulating G genotype was G1 (40.5%), followed by G2 (27.6%), G3 (19.4%), G9 (9.7%), G4 (2.5%) and G12 (0.4%). The predominant type of P genotypes was P[8] (69.6%), followed by P[4] (27.8%) and P[6] (2.3%). In this study, 13 G-P combinations were detected. From 2008 to 2010, G1P[8] was the most prevalent, followed by G3P[8]. Whereas, 2011 and 2012, G2P[4] was the most common, followed by G1P[8]. Rotavirus gastroenteritis is a common disease associated with significant morbidity, mortality and economic burden. Ongoing rotavirus surveillance to understand the distribution of G and P genotypes will be critical for the development of effective prevention measurements.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Kapikian AZ. / 1989 / Strategies for the development of a rotavirus vaccine against infantile diarrhea with an update on clinical trials of rotavirus vaccines / Adv Exp Med Biol 257 : 67 ~ 89
2. [학술지(정기간행물)] - Parashar UD. / 2009 / Global mortality associated with rotavirus disease among children in 2004 / J Infect Dis 1 : S9 ~ S15
3. [단행본] - Estes MK. / 2007 / Fields. Virology. Fifth ed / Lippincott Williams & Wilkins : 1917 ~ 1974
4. [학술지(정기간행물)] - Ciarlet M. / 2001 / Interactions between rotavirus and gastrointestinal cells / Curr Opin Microbiol 4 : 435 ~ 441
5. [학술지(정기간행물)] - Gorziglia M. / 1990 / Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4 / Proc Natl Acad Sci U S A 87 : 7155 ~ 7159
2. [학술지(정기간행물)] - Parashar UD. / 2009 / Global mortality associated with rotavirus disease among children in 2004 / J Infect Dis 1 : S9 ~ S15
3. [단행본] - Estes MK. / 2007 / Fields. Virology. Fifth ed / Lippincott Williams & Wilkins : 1917 ~ 1974
4. [학술지(정기간행물)] - Ciarlet M. / 2001 / Interactions between rotavirus and gastrointestinal cells / Curr Opin Microbiol 4 : 435 ~ 441
5. [학술지(정기간행물)] - Gorziglia M. / 1990 / Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4 / Proc Natl Acad Sci U S A 87 : 7155 ~ 7159
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