The effects of ventilation with high density oxygen on the strength of gastrointestinal anastomosis

Tevfik Eker; Volkan Genc; Yusuf Sevim; Ozge Cumaogullari; Menekse Ozcelik; Akin Firat Kocaay; Cemal Özben Ensari; Ozge Tugce Pasaoglu

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자료유형: 학술저널

저자정보: Tevfik Eker (Ankara University Medical School) Volkan Genc (Ankara University Medical School) Yusuf Sevim (Ankara Penal Institution Campus State Hospital) Ozge Cumaogullari (Ankara University Biotechnology Institute) Menekse Ozcelik (Ankara University Medical School) Akin Firat Kocaay (Ankara University Medical School) Cemal Özben Ensari (Antalya Education and Training Hospital) Ozge Tugce Pasaoglu (Gazi University Medical School)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.1

발행연도: 2015.6

수록면: 17 - 22 (6page)

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Purpose: The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses.
Methods: Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats and assigned to an oxygen/nitrous oxide mixture with a fraction of inspired oxygen of 30% in groups 1 and 3 and 80% in groups 2 and 4. The measurements of perianastomotic tissue oxygen pressure, bursting pressure, level of hydroxyproline were evaluated and compared in all groups.
Results: The perianastomotic tissue oxygen pressures, bursting pressures and levels of hydroxyproline were identified as significantly high in groups 2 and 4, administered a fraction of inspired oxygen of 80%, compared to groups 1 and 3, administered a fraction of inspired oxygen of 30%.
Conclusion: Perioperative supplemental oxygen contributes positively to the anastomotic healing.

#Anastomosis #Wistar rats #Oxygen

참고문헌 (19)

참고문헌 신청

[학술지(정기간행물)] - Chen C / 2012 / The art of bowel anastomosis / Scand J Surg 101 : 238 ~ 240

[학술지(정기간행물)] - Sheridan WG. / 1987 / Tissue oxygen tension as a predictor of colonic anastomotic healing / Dis Colon Rectum 30 : 867 ~ 871

[학술지(정기간행물)] - Garcia-Botello SA. / 2006 / Randomized clinical trial to evaluate the effects of perioperative supplemental oxygen administration on the colorectal anastomosis / Br J Surg 93 : 698 ~ 706

[학술지(정기간행물)] - Belda FJ. / 2005 / Supplemental perioperative oxygen and the risk of surgical wound infection : a randomized controlled trial / JAMA 294 : 2035 ~ 2042

[학술지(정기간행물)] - Hunt TK. / 1972 / The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis / Surg Gynecol Obstet 135 : 561 ~ 567

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