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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 학술저널
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- 발행연도
- 2011.2
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- 50 - 58 (9page)
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Epstein-Barr virus associated gastric lymphoepithelioma-like carcinoma (LELC) is characterized by the intensive infiltration of lymphoid cells, the presence of EBV, and the better prognosis over typical adenocarcinoma. Thus, it was assumable that viral latent proteins may be responsible for the recruitment of a certain T cell repertoire to EBV-associated gastric carcinoma. Methods: To examine above possibility, EBV gene expression in gastric carcinoma tissues and usage of TCR among the tumor infiltrating lymphocytes were analyzed. Results: EBV specific DNA and EBERs RNA were detected in 4 out of 30 patients. RT-PCR analysis revealed that all 4 of EBV-positive tumor tissues expressed EBNA1 mRNA and BARTs and LMP2a was detected only one sample out of 4. However, the EBNA2 and LMP-1 transcripts were not detected in these tissues. CD8<sup>+</sup> T cells were the predominant population of infiltrating lymphocytes in the EBV-positive gastric carcinoma. According to spectra type analysis of infiltrating T cells, 10 predominant bands were detected by TCR Vβ CDR3 specific RT-PCR from 4 EBV-positive tumor tissues. Sequence analysis of these bands revealed oligoclonal expansion of T cells. Conclusion: These findings suggest that clonally expanded T cells in vivo might be a population of cytotoxic T cells reactive to EBV-associated gastric carcinoma.
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참고문헌 (32)
참고문헌 신청
Rickinson AB / 2007 / Epstein-Barr virus, In Fields virology. 5th ed / Lippincott Williams & Wilkins :2655~2700
Kieff E / 2007 / Epstein-Barr Virus and its replication, In Fields Virology. 5th ed / Lippincott-Williams & Wilkins Publishers :2603~2654
Sample J / 1991 / Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site / Proc Natl Acad Sci U S A 88:6343~6347
Young LS / 2003 / Epstein-Barr virus and oncogenesis: from latent genes to tumours / Oncogene 22:5108~5121
Boon T / 1996 / Human tumor antigens recognized by T lymphocytes / J Exp Med 183:725~729
Kieff E / 2007 / Epstein-Barr Virus and its replication, In Fields Virology. 5th ed / Lippincott-Williams & Wilkins Publishers :2603~2654
Sample J / 1991 / Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site / Proc Natl Acad Sci U S A 88:6343~6347
Young LS / 2003 / Epstein-Barr virus and oncogenesis: from latent genes to tumours / Oncogene 22:5108~5121
Boon T / 1996 / Human tumor antigens recognized by T lymphocytes / J Exp Med 183:725~729
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