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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 135 - 154 (20page)
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초록· 키워드
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The great discovery of microRNAs (miRNAs) has revolutionized current cell biology and medical science. miRNAs are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3' untranslated region of specific messenger RNAs for degradation or translational repression. New members of the miRNA family are being discovered on a daily basis and emerging evidence has demonstrated that miRNAs play a major role in a wide range of developmental process including cell proliferation, cell cycle, cell differentiation, metabolism, apoptosis, developmental timing, neuronal cell fate, neuronal gene expression, brain morphogenesis, muscle differentiation and stem cell division. Moreover, a large number of studies have reported links between alterations of miRNA homeostasis and pathological conditions such as cancer, psychiatric and neurological diseases, cardiovascular disease, and autoimmune disease. Interestingly, in addition, miRNA deficiencies or excesses have been correlated with a number of clinically important diseases ranging from cancer to myocardial infarction. miRNAs can repress the gene translation of hundreds of their targets and are therefore well-positioned to target a multitude of cellular mechanisms. As a consequence of extensive participation in normal functions, it is quite logical to ask the question if abnormalities in miRNAs should have importance in human diseases. Great discoveries and rapid progress in the past few years on miRNAs provide the hope that miRNAs will in the near future have a great potential in the diagnosis and treatment of many diseases. Currently, an explosive literature has focussed on the role of miRNA in human cancer and cardiovascular disease. In this review, I briefly summarize the explosive current studies about involvement of miRNA in various human cancers and cardiovascular disease.
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참고문헌 (141)
참고문헌 신청
O'Neill LA / 2011 / MicroRNAs: the fine-tuners of Toll-like receptor signalling / Nat Rev Immunol 11:163~175
O'Connell RM / 2010 / Physiological and pathological roles for microRNAs in the immune system / Nat Rev Immunol 10:111~122
Baltimore D / 2008 / MicroRNAs: new regulators of immune cell development and function / Nat Immunol 9:839~845
Slaby O / 2009 / MicroRNAs in colorectal cancer: translation of molecular biology into clinical application / Mol Cancer 8:102
Small EM / 2011 / Pervasive roles of microRNAs in cardiovascular biology / Nature 469:336~342
O'Connell RM / 2010 / Physiological and pathological roles for microRNAs in the immune system / Nat Rev Immunol 10:111~122
Baltimore D / 2008 / MicroRNAs: new regulators of immune cell development and function / Nat Immunol 9:839~845
Slaby O / 2009 / MicroRNAs in colorectal cancer: translation of molecular biology into clinical application / Mol Cancer 8:102
Small EM / 2011 / Pervasive roles of microRNAs in cardiovascular biology / Nature 469:336~342
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