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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 155 - 162 (8page)
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초록· 키워드
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Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA) and induces inflammation. In this study we attempted to ascertain if there are endogenous host molecules controlling the production of cytokines and chemokines. Two candidates, ribosomal protein L19 and L22, were analyzed to determine if they influence cytokine production followed by TLR3 activation. In this study we report that L19 acts upon production of IP-10 or IL-8 differently in glioblastoma cells. Methods: L19 or L22 was transfected into HEK293-TLR3, A549 or A172 cells. After treatment with several inhibitors of NF-κB , PI3K, p38 or ERK, production of IL-8 or IP-10 was measured by ELISA. siRNA was introduced to suppress expression of L19. After Vesicular stomatitis virus infection, viral multiplication was measured by western blot. Results: L19 increased ERK activation to produce IL-8. In A172 cells, in which TLR3 is expressed at endosomes, L19 inhibited interferon regulatory factor 3 (IRF3) activation and IP-10 production to facilitate viral multiplication, whereas L19 inhibited viral multiplication in A549 cells bearing TLR3 on their cell membrane. Conclusion: Our results suggest that L19 regulates TLR3 signaling, which is cell type specific and may be involved in pathogenesis of autoimmune diseases and chronic inflammatory diseases.
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참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Wang T / 2004 / Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis / Nat Med 10 : 1366 ~ 1373
2. [학술지(정기간행물)] - Diamond MS / 2004 / West Nile virus: crossing the blood-brain barrier / Nat Med 10 : 1294 ~ 1295
3. [학술지(정기간행물)] - Le Goffic R / 2006 / Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia / PLoS Pathog 2 : e53 ~
4. [학술지(정기간행물)] - Guillot L / 2005 / Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus / J Biol Chem 280 : 5571 ~ 5580
5. [학술지(정기간행물)] - Rudd BD / 2006 / Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection / J Immunol 176 : 1937 ~ 1942
2. [학술지(정기간행물)] - Diamond MS / 2004 / West Nile virus: crossing the blood-brain barrier / Nat Med 10 : 1294 ~ 1295
3. [학술지(정기간행물)] - Le Goffic R / 2006 / Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia / PLoS Pathog 2 : e53 ~
4. [학술지(정기간행물)] - Guillot L / 2005 / Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus / J Biol Chem 280 : 5571 ~ 5580
5. [학술지(정기간행물)] - Rudd BD / 2006 / Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection / J Immunol 176 : 1937 ~ 1942
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