지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 196 - 202 (7page)
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초록· 키워드
오류제보하기
B cell-activating factor belonging to the TNF family (BAFF) is primarily expressed by macrophages and dendritic cells, and stimulates B cell proliferation, differentiation, survival, and Ig production. In the present study, we explored the effect of activin A on BAFF expression by APCs. Methods: To investigate the effect of activin A on BAFF expression by mouse APCs, we measured the level of BAFF expression at the transcriptional and protein levels using RT-PCR and ELISA. Results: Activin A markedly enhanced BAFF expression in mouse macrophages and dendritic cells at both the transcriptional and protein levels. SB431542, an activin receptor-like kinase 4 (ALK4) inhibitor, completely abrogated activin A-induced BAFF transcription. Furthermore, overexpression of DN-Smad3 abolished activin-induced BAFF expression at the transcriptional and protein levels. Conclusion: These results demonstrate that activin A can enhance BAFF expression through ALK4-Smad3 pathway.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Craxton A / 2003 / Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF / Blood 101 : 4464 ~ 4471
2. [학술지(정기간행물)] - Dubois B / 1998 / Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes / J Immunol 161 : 2223 ~ 2231
3. [학술지(정기간행물)] - Dubois B / 1997 / Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes / J Exp Med 185 : 941 ~ 951
4. [학술지(정기간행물)] - Fagarasan S / 2000 / T-Independent immune response: new aspects of B cell biology / Science 290 : 89 ~ 92
5. [학술지(정기간행물)] - Snapper CM / 1996 / model for induction of T cell-independent humoral immunity in response to polysaccharide antigens / J Immunol 157 : 2229 ~ 2233
2. [학술지(정기간행물)] - Dubois B / 1998 / Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes / J Immunol 161 : 2223 ~ 2231
3. [학술지(정기간행물)] - Dubois B / 1997 / Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes / J Exp Med 185 : 941 ~ 951
4. [학술지(정기간행물)] - Fagarasan S / 2000 / T-Independent immune response: new aspects of B cell biology / Science 290 : 89 ~ 92
5. [학술지(정기간행물)] - Snapper CM / 1996 / model for induction of T cell-independent humoral immunity in response to polysaccharide antigens / J Immunol 157 : 2229 ~ 2233
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