지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 223 - 226 (4page)
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초록· 키워드
오류제보하기
Although exercise-induced growth factors such as Insulin-like growth factor-I (IGF-I) are known to affect various aspects of physiology in skeletal muscle cells, the molecular mechanism by which IGF-I modulates anti-inflammatory effects in these cells is presently unknown. Here, we showed that IGF-I stimulation suppresses the expression of toll-like receptor 4 (TLR4), a key innate immune receptor. A pharmacological inhibitor study further showed that PI3K/Akt signaling pathway is required for IGF-I-mediated negative regulation of TLR4 expression. Furthermore, IGF-I treatment reduced the expression of various NF-κB -target genes such as TNF-α and IL-6. Taken together, these findings indicate that the anti-inflammatory effect of exercise may be due, at least in part, to IGF-I-induced suppression of TLR4 and subsequent downregulation of the TLR4-dependent inflammatory signaling pathway.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
1. [학술지(정기간행물)] - Bruunsgaard H / 2003 / Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people / Clin Exp Immunol 132 : 24 ~ 31
2. [학술지(정기간행물)] - Fessler MB / 2009 / Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome / Curr Opin Lipidol 20 : 379 ~ 385
3. [학술지(정기간행물)] - Oliveira AG / 2011 / Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats / Diabetes 60 : 784 ~ 796
4. [학술지(정기간행물)] - Steinman RM / 2006 / Dendritic cells: translating innate to adaptive immunity / Curr Top Microbiol Immunol 311 : 17 ~ 58
5. [학술지(정기간행물)] - Cooper DM / 2007 / Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity / J Appl Physiol 103 : 700 ~ 709
2. [학술지(정기간행물)] - Fessler MB / 2009 / Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome / Curr Opin Lipidol 20 : 379 ~ 385
3. [학술지(정기간행물)] - Oliveira AG / 2011 / Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats / Diabetes 60 : 784 ~ 796
4. [학술지(정기간행물)] - Steinman RM / 2006 / Dendritic cells: translating innate to adaptive immunity / Curr Top Microbiol Immunol 311 : 17 ~ 58
5. [학술지(정기간행물)] - Cooper DM / 2007 / Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity / J Appl Physiol 103 : 700 ~ 709
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