지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.10
- 수록면
- 245 - 252 (8page)
이용수
초록· 키워드
오류제보하기
Antimicrobial peptides/proteins are ancient and naturally-occurring antibiotics in innate immune responses in a variety of organisms. Additionally, these peptides have been recognized as important signaling molecules in regulation of both innate and adaptive immunity. During mycobacterial infection, antimicrobial peptides including cathelicidin, defensin, and hepcidin have antimicrobial activities against mycobacteria, making them promising candidates for future drug development. Additionally, antimicrobial peptides act as immunomodulators in infectious and inflammatory conditions. Multiple crucial functions of cathelicidins in antimycobacterial immune defense have been characterized not only in terms of direct killing of mycobacteria but also as innate immune regulators, i.e., in secretion of cytokines and chemokines, and mediating autophagy activation. Defensin families are also important during mycobacterial infection and contribute to antimycobacterial defense and inhibition of mycobacterial growth both in vitro and in vivo. Hepcidin, although its role in mycobacterial infection has not yet been characterized, exerts antimycobacterial effects in activated macrophages. The present review focuses on recent efforts to elucidate the roles of host defense peptides in innate immunity to mycobacteria.
목차
등록된 정보가 없습니다.
참고문헌 (62)
참고문헌 신청
WHO / 2010 / Global Tubercalosis Control 2010 / WHO
Pieters J / 2008 / Mycobacterium tuberculosis and the macrophage: maintaining a balance / Cell Host Microbe 3:399~407
Flynn JL / 2001 / Tuberculosis: latency and reactivation / Infect Immun 69:4195~4201
Zaiou M / 2007 / Multifunctional antimicrobial peptides: therapeutic targets in several human diseases / J Mol Med 85:317~329
Liu PT / 2008 / Human macrophage host defense against Mycobacterium tuberculosis / Curr Opin Immunol 20:371~376
Pieters J / 2008 / Mycobacterium tuberculosis and the macrophage: maintaining a balance / Cell Host Microbe 3:399~407
Flynn JL / 2001 / Tuberculosis: latency and reactivation / Infect Immun 69:4195~4201
Zaiou M / 2007 / Multifunctional antimicrobial peptides: therapeutic targets in several human diseases / J Mol Med 85:317~329
Liu PT / 2008 / Human macrophage host defense against Mycobacterium tuberculosis / Curr Opin Immunol 20:371~376
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Ribosomally Synthesiszed Antimicrobial Peptides (Bacteriocins) in Lactic Acid Bacteria : A Review
Ingolf F. Nes
,
Sung-Sik Yoon
,
Dzung B. Diep
Food Science and Biotechnology
2007
.10
Smart Antimicrobial Peptide Micelle
Seong-Cheol PARK
,
Yung-Hun PARK
,
Mi-Kyeong JANG
한국생물공학회 학술대회
2020
.10
Antimicrobial Activity and Action of Mechanism of Antimicrobial Peptide and Its Analog Peptides against Acinetobacter baumannii and Staphylococcus aureus
Hee Joo Pa
,
k
,
Yoonkyung Pa
외 1명
한국미생물학회 학술대회논문집
2019
.04
Skin-infected Bactericidal Activity of Antimicrobial Peptide against Multidrug-resistant Staphylococcus aureus
Jong-Kook Lee
,
Tudo
,
Luchian
외 2명
한국미생물학회 학술대회논문집
2019
.04
Antimicrobial and Antibiofilm Activities and Mechanisms of Action of Antimicrobial Peptides against Klebsiella pneumoniae
Jonggwan Pa
,
k
,
Chang Ho Seo
외 2명
한국미생물학회 학술대회논문집
2019
.04
최근 본 자료
댓글(0)
0