지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 358 - 363 (6page)
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초록· 키워드
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Traditionally, interferon-γ (IFN-γ) was regarded as a pro-inflammatory cytokine, however, recent reports suggested role of IFN-γ in immune tolerance. In our previous report, we could induce tolerance to male antigen (HY) just by male islet transplantation in wild type C57BL/6 mice without any immunological intervention. We tried to investigate the influence of IFN-γ deficiency on tolerance induction by male islet transplantation. Methods: To examine the immunogenicity of male tissue in the absence of IFN-γ, we transplanted male IFN-γ knock-out (KO) skin to female IFN-γ KO mice. Next, we analyzed male IFN-γ KO islet to streptozotocin-induced diabetic female IFN-γ KO mice. And, we checked the functionality of grafted islet by graft removal and insulin staining. Results: As our previous results in wild type C57BL/6 mice, female IFN-γ KO mice rejected male IFN-γ KO skin within 29 days, and did not reject male IFN-γ KO islet. The maintenance of normal blood glucose level was dependent on the presence of grafted male islet. And the male islet recipient did not reject 2nd challenge of male islet graft also. Conclusion: Deficiency of IFN-γ does not have influence on the result of male skin graft and male islet transplantation. Conclusively, male islet transplantation induced T cell tolerance is not dependent on the presence of IFN-γ.
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참고문헌 (29)
참고문헌 신청
Millrain M / 2001 / Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis / J Immunol 167:3756~3764
Simpson E / 1997 / The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning / Annu Rev Immunol 15:39~61
Yoon IH / 2008 / Pancreatic islets induce CD4(+) [corrected] CD25(-)Foxp3(+) [corrected] T-cell regulated tolerance to HY-mismatched skin grafts / Transplantation 86:1352~1360
Kelchtermans H / 2008 / How interferon-gamma keeps autoimmune diseases in check / Trends Immunol 29:479~486
Manoury-Schwartz B / 1997 / High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors / J Immunol 158:5501~5506
Simpson E / 1997 / The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning / Annu Rev Immunol 15:39~61
Yoon IH / 2008 / Pancreatic islets induce CD4(+) [corrected] CD25(-)Foxp3(+) [corrected] T-cell regulated tolerance to HY-mismatched skin grafts / Transplantation 86:1352~1360
Kelchtermans H / 2008 / How interferon-gamma keeps autoimmune diseases in check / Trends Immunol 29:479~486
Manoury-Schwartz B / 1997 / High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors / J Immunol 158:5501~5506
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