지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 424 - 427 (4page)
이용수
초록· 키워드
오류제보하기
The nucleotide-oligomerization domain (NOD) proteins are members of the NOD-like receptor (NLR) family, which are intracellular and cytoplasmic receptors. We analyzed the role of NODs for cytokine production by macrophages infected with intracellular pathogen M. leprae, the causative agent of leprosy. Production of pro-inflammatory cytokines such as IL-1β and TNF-α was inhibited in the presence of cytochalasin D, an agent blocking phagocytosis, suggesting that intracellular signaling was, partially, required for macrophage activation to M. leprae infection. Next, we investigated the role of NOD1 and NOD2 proteins on NF-κB activation and cytokine expression. Treatment with M. leprae significantly increased NF-κB activation and expression of TNF-α and IL-1β in NOD1- and NOD2-transfected cells. Interestingly, their activation and expression were inhibited by cytochalasin D, suggesting that stimulation of NOD proteins may be associated with the enhancement of cytokine production in host to M. leprae.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Kang TJ / 2002 / A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy / Cytokine 20:56~62
Kang TJ / 2004 / Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation / Immunology 112:674~680
Kang TJ / 2010 / Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium Leprae infection / Mediators Inflamm 2010:708713
Philpott DJ / 2004 / The role of Toll-like receptors and Nod proteins in bacterial infection / Mol Immunol 41:1099~1108
Franchi L / 2008 / Intracellular NOD-like receptors in innate immunity, infection and disease / Cell Microbiol 10:1~8
Kang TJ / 2004 / Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation / Immunology 112:674~680
Kang TJ / 2010 / Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium Leprae infection / Mediators Inflamm 2010:708713
Philpott DJ / 2004 / The role of Toll-like receptors and Nod proteins in bacterial infection / Mol Immunol 41:1099~1108
Franchi L / 2008 / Intracellular NOD-like receptors in innate immunity, infection and disease / Cell Microbiol 10:1~8
이 논문의 저자 정보
최근 본 자료
댓글(0)
0