지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.2
- 수록면
- 18 - 26 (9page)
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초록· 키워드
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Vitamin C is an essential nutrient for maintaining human life. Vitamin C insufficiency in the plasma is closely related with the development of scurvy. However, in vivo kinetics of vitamin C regarding its storage and consumption is still largely unknown. Methods: We used GUlo<sup>-/-</sup> mice, which cannot synthesize vitamin C like human. Vitamin C level in plasma and organs from GUlo<sup>-/-</sup> mice was examined, and it compared with the level of wild-type mice during 5 weeks. Results: The significant weight loss of GUlo<sup>-/-</sup> mice was shown at 3 weeks after vitamin C withdrawal. However, there was no differences between wild-type and vitamin C-supplemented GUlo<sup>-/-</sup> mice (3.3 g/L in drinking water). The concentration of vitamin C in plasma and organs was significantly decreased at 1 week after vitamin C withdrawal. Vitamin C is preferentially deposited in adrenal gland, lymph node, lung, and brain. There were no significant changes in the numbers and CD4/CD8 ratio of splenocytes in GUlo<sup>-/-</sup> mice with vitamin C withdrawal for 4 weeks. And the architecture of spleen in GUlo<sup>-/-</sup> mice was disrupted at 5 weeks after vitamin C withdrawal. Conclusion: The vitamin C level of GUlo<sup>-/-</sup> mice was considerably decreased from 1 week after vitamin C withdrawal. Vitamin C is preferentially stored in some organs such as brain, adrenal gland and lung.
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