지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 176 - 180 (5page)
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초록· 키워드
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Although the majority of research on CD137 has been directed to T cells, it is becoming clear that this molecule has distinct functions in other lineages of cells, including non-hematopoietic cells. In particular, emerging evidence suggests that the CD137-its ligand (CD137L) network involving immune cells and non-immune cells, directly or indirectly regulates inflammation in both positive and negative manners. Bidirectional signaling through both CD137 and CD137L is critical in the evolution of inflammation: 1) CD137L signaling plays an indispensible role in the activation and recruitment of neutrophils by inducing the production of proinflammatory cytokines and chemokines in hematopoietic and non-hematopoietic cells such as macrophages, endothelial cells and epithelial cells; 2) CD137 signaling in NK cells and T cells is required for their activation and can influence other cells participating in inflammation via either their production of proinflammatory cytokines or engagement of CD137L by their cell surface CD137: 3) CD137 signaling can suppress inflammation by controlling regulatory activities of dendritic cells and regulatory T cells. As recognition grows of the role of dysregulated CD137 or CD137L stimulation in inflammatory diseases, significant efforts will be needed to develop antagonists to CD137 or CD137L.
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참고문헌 (34)
참고문헌 신청
Medzhitov, R. / 2008 / Origin and physiological roles of inflammation / Nature 454:428~435
Barton, G. M / 2008 / A calculated response: control of inflammation by the innate immune system / J. Clin. Invest 118:413~420
Seo, S. K. / 2004 / 4-1BB-mediated immunotherapy of rheumatoid arthritis / Nat. Med 10:1088~1094
Olofsson, P. S. / 2008 / CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice / Circulation 117:1292~1301
Jeon, H. J. / 201003 / CD137 (4-1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice / CIRCULATION 121(9):1124~126
Barton, G. M / 2008 / A calculated response: control of inflammation by the innate immune system / J. Clin. Invest 118:413~420
Seo, S. K. / 2004 / 4-1BB-mediated immunotherapy of rheumatoid arthritis / Nat. Med 10:1088~1094
Olofsson, P. S. / 2008 / CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice / Circulation 117:1292~1301
Jeon, H. J. / 201003 / CD137 (4-1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice / CIRCULATION 121(9):1124~126
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