지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 277 - 283 (7page)
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초록· 키워드
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Vitamin C is an essential water-soluble nutrient which primarily exerts its effect on host defense mechanisms and immune homeostasis, but the mechanism related to immune-potentiation is poorly understood. Since dendritic cells (DCs) are known as a potent antigen presenting cell (APC) that could enhance the antigen specific immune responses, we investigate the effects of vitamin C on activation of DCs and its related mechanism by using dendritic cell lines, DC-1. First, we found that there was no damage on DC-1 by 2.5 mM of vitamin C. In the presence of vitamin C, the expression of CD80, CD86, and MHC molecules was increased, but it was decreased by the pre-treatment of SB203580, p38 MAPK-specific inhibitor. We confirmed the phosphorylation of p38 MAPK was increased by the treatment of vitamin C. Taken together, these results suggest that vitamin C could enhance the activity of dendritic cells via the up-regulation of the expression of CD80, CD86, and MHC molecules and the activation of p38 MAPK is related to this process.
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참고문헌 (36)
참고문헌 신청
Härtel, C. / 2004 / Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes / Cytokine 27:101~106
Hartel, C / 2007 / Immunomodulatory effect of vitamin C on intracytoplasmic cytokine production in neonatal cord blood cells / Neonatology 91:54~60
Bergsten, P. / 1990 / Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation / J. Biol. Chem 265:2584~2587
May, J. M / 2005 / Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide / Free Radic. Biol. Med 39:1449~1459
Washko, P. / 1991 / Ascorbic acid in human neutrophils / Am. J. Clin. Nutr 54(6):1221S~1227S
Hartel, C / 2007 / Immunomodulatory effect of vitamin C on intracytoplasmic cytokine production in neonatal cord blood cells / Neonatology 91:54~60
Bergsten, P. / 1990 / Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation / J. Biol. Chem 265:2584~2587
May, J. M / 2005 / Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide / Free Radic. Biol. Med 39:1449~1459
Washko, P. / 1991 / Ascorbic acid in human neutrophils / Am. J. Clin. Nutr 54(6):1221S~1227S
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