지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 291 - 295 (5page)
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초록· 키워드
오류제보하기
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-α. The fraction also increased the production of TGF-β and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-α, as well as secretion of VEGF, TGF-β and HS may have a new bioactive material for the treatment of skin wound.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Singer, A. J / 1999 / Cutaneous wound healing / N. Engl. J. Med 341:738~746
Spelman, K / 2006 / Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators / Altern. Med. Rev 11:128~150
Levy, L / 1975 / The activity of chaulmoogra acids against Mycobacterium leprae / Am. Rev. Respir. Dis 111:703~705
Oommen, S. T. / 1999 / Effect of oil of hydnocarpus on wound healing / Int. J. Lepr. Other Mycobact. Dis 67:154~158
Oommen, S. T. / 2000 / The effect of oil of hydnocarpus on excision wounds / Int. J. Lepr. Other Mycobact. Dis 68:69~70
Spelman, K / 2006 / Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators / Altern. Med. Rev 11:128~150
Levy, L / 1975 / The activity of chaulmoogra acids against Mycobacterium leprae / Am. Rev. Respir. Dis 111:703~705
Oommen, S. T. / 1999 / Effect of oil of hydnocarpus on wound healing / Int. J. Lepr. Other Mycobact. Dis 67:154~158
Oommen, S. T. / 2000 / The effect of oil of hydnocarpus on excision wounds / Int. J. Lepr. Other Mycobact. Dis 68:69~70
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