지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 187 - 200 (14page)
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초록· 키워드
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Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are the most common cause of genital ulceration in humans worldwide. Typically, HSV-1 and 2 infections via mucosal route result in a lifelong latent infection after peripheral replication in mucosal tissues, thereby providing potential transmission to neighbor hosts in response to reactivation. To break the transmission cycle, immunoprophylactics and therapeutic strategies must be focused on prevention of infection or reduction of infectivity at mucosal sites. Currently, our understanding of the immune responses against mucosal infection of HSV remains intricate and involves a balance between innate signaling pathways and the adaptive immune responses. Numerous studies have demonstrated that HSV mucosal infection induces type I interferons (IFN) via recognition of Toll-like receptors (TLRs) and activates multiple immune cell populations, including NK cells, conventional dendritic cells (DCs), and plasmacytoid DCs. This innate immune response is required not only for the early control of viral replication at mucosal sites, but also for establishing adaptive immune responses against HSV antigens. Although the contribution of humoral immune response is controversial, CD4<sup>+</sup> Th1 T cells producing IFN-γ are believed to play an important role in eradicating virus from the hosts. In addition, the recent experimental successes of immunoprophylactic and therapeutic compounds that enhance resistance and/or reduce viral burden at mucosal sites have accumulated. This review focuses on attempts to modulate innate and adaptive immunity against HSV mucosal infection for the development of prophylactic and therapeutic strategies. Notably, cells involved in innate immune regulations appear to shape adaptive immune responses. Thus, we summarized the current evidence of various immune mediators in response to mucosal HSV infection, focusing on the importance of innate immune responses.
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참고문헌 (138)
참고문헌 신청
1. [학술지(정기간행물)] - Mansur, D. S. / 2005 / Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1 / Am. J. Pathol 166 : 1419 ~ 1426
2. [단행본] - Roizman. B. / 2001 / Fields Virology / Lippincott Williams & Wilkins : 2399 ~ 2459
3. [학술지(정기간행물)] - Ellermann-Eriksen, S. / 2005 / Macrophages and cytokines in the early defence against herpes simplex virus / Virol. J 2 : 59 ~
4. [학술지(정기간행물)] - Chan, T. / 2011 / Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa / J. Reprod. Immunol 88 : 210 ~ 218
5. [학술지(정기간행물)] - Wakimoto, H. / 2003 / Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells / Gene Ther 10 : 983 ~ 990
2. [단행본] - Roizman. B. / 2001 / Fields Virology / Lippincott Williams & Wilkins : 2399 ~ 2459
3. [학술지(정기간행물)] - Ellermann-Eriksen, S. / 2005 / Macrophages and cytokines in the early defence against herpes simplex virus / Virol. J 2 : 59 ~
4. [학술지(정기간행물)] - Chan, T. / 2011 / Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa / J. Reprod. Immunol 88 : 210 ~ 218
5. [학술지(정기간행물)] - Wakimoto, H. / 2003 / Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells / Gene Ther 10 : 983 ~ 990
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