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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 201 - 206 (6page)
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IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.
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참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Moussion, C. / 2008 / The IL-1lLike cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells: a novel ‘alarmin’? / PLoS One 3 : e3331 ~
2. [학술지(정기간행물)] - Liew, F. Y. / 2010 / Disease-associated functions of IL-33: the new kid in the IL-1 family / Nat. Rev. Immunol 10 : 103 ~ 110
3. [학술지(정기간행물)] - Le, H. / 2013 / Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies / Front. Immunol 4 : 104 ~
4. [학술지(정기간행물)] - Romani, L. / 2011 / Immunity to fungal infections / Nat. Rev. Immunol 11 : 275 ~ 288
5. [학술지(정기간행물)] - Lionakis, M. S. / 2013 / Candida and host determinants of susceptibility to invasive candidiasis / PLoS Pathog 9 : e1003079 ~
2. [학술지(정기간행물)] - Liew, F. Y. / 2010 / Disease-associated functions of IL-33: the new kid in the IL-1 family / Nat. Rev. Immunol 10 : 103 ~ 110
3. [학술지(정기간행물)] - Le, H. / 2013 / Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies / Front. Immunol 4 : 104 ~
4. [학술지(정기간행물)] - Romani, L. / 2011 / Immunity to fungal infections / Nat. Rev. Immunol 11 : 275 ~ 288
5. [학술지(정기간행물)] - Lionakis, M. S. / 2013 / Candida and host determinants of susceptibility to invasive candidiasis / PLoS Pathog 9 : e1003079 ~
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