지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 227 - 234 (8page)
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초록· 키워드
오류제보하기
The intestinal immune system has an ability to distinguish between the microbiota and pathogenic bacteria, and then activate pro-inflammatory pathways against pathogens for host defense while remaining unresponsive to the microbiota and dietary antigens. In the intestine, abnormal activation of innate immunity causes development of several inflammatory disorders such as inflammatory bowel diseases (IBD). Thus, activity of innate immunity is finely regulated in the intestine. To date, multiple innate immune cells have been shown to maintain gut homeostasis by preventing inadequate adaptive immune responses in the murine intestine. Additionally, several innate immune subsets, which promote Th1 and Th17 responses and are implicated in the pathogenesis of IBD, have recently been identified in the human intestinal mucosa. The demonstration of both murine and human intestinal innate immune subsets contributing to regulation of adaptive immunity emphasizes the conserved innate immune functions across species and might promote development of the intestinal innate immunity-based clinical therapy.
목차
INTRODUCTION
REGULATION OF ADAPTIVE IMMUNITY BY THE INTESTINAL INNATE IMMUNE SUBSETS
REGULATION OF IBD BY HUMAN MYELOID SUBSETS
CONCLUSION
REFERENCES
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Maloy, K. J. / 2008 / IL-23 and Th17 cytokines in intestinal homeostasis / Mucosal Immunol 1 : 339 ~ 349
2. [학술지(정기간행물)] - Shevach, E. M. / 2009 / Mechanisms of Foxp3＋ T regulatory cell-mediated suppression / Immunity 30 : 636 ~ 645
3. [학술지(정기간행물)] - Sakaguchi, S. / 2003 / The origin of Foxp3-expressing CD4＋ regulatory T cells: thymus or periphery / J. Clin. Invest 112 : 1310 ~ 1312
4. [학술지(정기간행물)] - Asseman, C. / 1999 / An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation / J. Exp. Med 190 : 995 ~ 1004
5. [학술지(정기간행물)] - Garrett, W. S. / 2010 / Homeostasis and inflammation in the intestine / Cell 140 : 859 ~ 870
2. [학술지(정기간행물)] - Shevach, E. M. / 2009 / Mechanisms of Foxp3＋ T regulatory cell-mediated suppression / Immunity 30 : 636 ~ 645
3. [학술지(정기간행물)] - Sakaguchi, S. / 2003 / The origin of Foxp3-expressing CD4＋ regulatory T cells: thymus or periphery / J. Clin. Invest 112 : 1310 ~ 1312
4. [학술지(정기간행물)] - Asseman, C. / 1999 / An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation / J. Exp. Med 190 : 995 ~ 1004
5. [학술지(정기간행물)] - Garrett, W. S. / 2010 / Homeostasis and inflammation in the intestine / Cell 140 : 859 ~ 870
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UCI(KEPA) : I410-ECN-0101-2016-511-001745950