지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 240 - 248 (9page)
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초록· 키워드
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In this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lymphoid tissue-like structure, with those in tonsils, which are normal secondary lymphoid tissues. Firstly, we found that CD4?CD11b＋ macrophages were the major population in RA synovial fluid and that B cells were the major population in tonsils. In addition, synovial fluid from patients with osteoarthritis, which is a degenerative joint disease, contained CD4＋CD11b＋ monocytes as the major immune cell population. Secondly, we categorized three groups based on the proportion of macrophages found in RA synovial fluid: (1) the macrophage-high group, which contained more than 80% macrophages; (2) the macrophage-intermediate group, which contained between 40% and 80% macrophages; and (3) the macrophage-low group, which contained less than 40% macrophages. In the macrophage-low group, more lymphoid tissue inducer (LTi)-like cells were detected, and the expression of OX40L and TRANCE in these cells was higher than that in the other groups. In addition, in this group, the suppressive function of regulatory T cells was downregulated. Finally, CXCL13 expression was higher in RA synovial fluid than in tonsils, but CCL21 expression was comparable in synovial fluid from all groups and in tonsils. These data demonstrate that increased lymphocyte infiltration in RA synovial fluid is correlated with an increase in LTi-like cells and the elevation of the chemokine expression.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Yanni, G. / 1994 / Synovial tissue macrophages and joint erosion in rheumatoid arthritis / Ann. Rheum. Dis 53 : 39 ~ 44
2. [학술지(정기간행물)] - Kinne, R. W. / 2000 / Macrophages in rheumatoid arthritis / Arthritis Res 2 : 189 ~ 202
3. [학술지(정기간행물)] - Cutolo, M. / 1993 / Macrophages, synovial tissue and rheumatoid arthritis / Clin. Exp. Rheumatol 11 : 331 ~ 339
4. [학술지(정기간행물)] - Young, C. L. / 1984 / Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis / Arthritis Rheum 27 : 32 ~ 39
5. [학술지(정기간행물)] - Schroder, A. E. / 1996 / Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis / Proc. Natl. Acad. Sci. U. S. A 93 : 221 ~ 225
2. [학술지(정기간행물)] - Kinne, R. W. / 2000 / Macrophages in rheumatoid arthritis / Arthritis Res 2 : 189 ~ 202
3. [학술지(정기간행물)] - Cutolo, M. / 1993 / Macrophages, synovial tissue and rheumatoid arthritis / Clin. Exp. Rheumatol 11 : 331 ~ 339
4. [학술지(정기간행물)] - Young, C. L. / 1984 / Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis / Arthritis Rheum 27 : 32 ~ 39
5. [학술지(정기간행물)] - Schroder, A. E. / 1996 / Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis / Proc. Natl. Acad. Sci. U. S. A 93 : 221 ~ 225
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UCI(KEPA) : I410-ECN-0101-2016-511-001745970