지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 75 - 79 (5page)
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초록· 키워드
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Evidence for immunoregulatory roles of prostaglandins (PGs) is accumulating. Since our observation of PG production by human follicular dendritic cells (FDCs), we investigated the regulatory mechanism of PG production in FDC and attempted to understand the functions of released PGs in the responses of adjacent lymphocytes. Here, using FDC-like cells, HK cells, we analyzed protein expression alterations in cyclooxygenase-2 (COX-2) in the presence of IL-4 or histone deacetylase (HDAC) inhibitors. Both IL-4 and HDAC inhibitors suppressed COX-2 expression in dose-dependent manners. Their effect was specific to COX-2 and did not reach to COX-1 expression. Interestingly, HDAC inhibitors gave rise to an opposing effect on COX-2 expression in peripheral blood monocytes. Our results suggest that IL-4 may regulate COX-2 expression in FDCs by affecting chromatin remodeling and provide insight into the role of cellular interactions between T cells and FDC during the GC reaction. Given the growing interests in wide-spectrum HDAC inhibitors, the differential results on COX-2 expression in HK cells and monocytes raise cautions on their clinical use.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Deshane, J / 2010 / Follicular dendritic cell makes environmental sense / Immunity 33:2~4
Lindhout, E. / 1999 / Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells / J. Immunol 162:5949~5956
Fakher, M. / 2001 / Follicular dendritic cell accessory activity crosses MHC and species barriers / Eur. J. Immunol 31:176~185
Lee, I. Y. / 2008 / Human follicular dendritic cells interact with T cells via expression and regulation of cyclooxygenases and prostaglandin E and I synthases / J. Immunol 180:1390~1397
Kim, H. S. / 1994 / Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes / J. Immunol 153:2951~2961
Lindhout, E. / 1999 / Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells / J. Immunol 162:5949~5956
Fakher, M. / 2001 / Follicular dendritic cell accessory activity crosses MHC and species barriers / Eur. J. Immunol 31:176~185
Lee, I. Y. / 2008 / Human follicular dendritic cells interact with T cells via expression and regulation of cyclooxygenases and prostaglandin E and I synthases / J. Immunol 180:1390~1397
Kim, H. S. / 1994 / Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes / J. Immunol 153:2951~2961
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UCI(KEPA) : I410-ECN-0101-2016-511-001745945