지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 142 - 149 (8page)
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초록· 키워드
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Lung fibrosis is a life-threatening disease caused by overt or insidious inflammatory responses. However, the mechanism of tissue injury-induced inflammation and subsequent fibrogenesis remains unclear. Recently, we and other groups reported that Th17 responses play a role in amplification of the inflammatory phase in a murine model induced by bleomycin (BLM). Osteopontin (OPN) is a cytokine and extracellular-matrix-associated signaling molecule. However, whether tissue injury causes inflammation and consequent fibrosis through OPN should be determined. In this study, we observed that BLM-induced lung inflammation and subsequent fibrosis was ameliorated in OPNdeficient mice. OPN was expressed ubiquitously in the lung parenchymal and bone-marrow-derived components and OPN from both components contributed to pathogenesis following BLM intratracheal instillation. Th17 differentiation of CD4<SUP>+</SUP> αβ T cells and IL-17-producing γδ T cells was significantly reduced in OPN-deficient mice compared to WT mice. In addition, Th1 differentiation of CD4+ αβ T cells and the percentage of IFN-γ-producing γδ T cells increased. T helper cell differentiation in vitro revealed that OPN was preferentially upregulated in CD4<SUP>+</SUP> T cells under Th17 differentiation conditions. OPN expressed in both parenchymal and bone marrow cell components and contributed to BLM-induced lung inflammation and fibrosis by affecting the ratio of pathogenic IL-17/protective IFN-γ T cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (40)
참고문헌 신청
[학술지(정기간행물)] - Wynn, T. A. / 2012 / Mechanisms of fibrosis:therapeutic translation for fibrotic disease / Nat. Med 18 : 1028 ~ 1040
[학술지(정기간행물)] - Wynn, T. A. / 2011 / Integrating mechanisms of pulmonary fibrosis / J. Exp. Med 208 : 1339 ~ 1350
[학술지(정기간행물)] - Wick, G. / 2013 / The immunology of fibrosis / Annu. Rev. Immunol 31 : 107 ~ 135
[학술지(정기간행물)] - Lo Re, S. / 2010 / IL-17A-producing gammadelta T Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis / J. Immunol 184 : 6367 ~ 6377
[학술지(정기간행물)] - Sonnenberg, G. F. / 2010 / Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A / J. Exp. Med 207 : 1293 ~ 12305
[학술지(정기간행물)] - Wynn, T. A. / 2011 / Integrating mechanisms of pulmonary fibrosis / J. Exp. Med 208 : 1339 ~ 1350
[학술지(정기간행물)] - Wick, G. / 2013 / The immunology of fibrosis / Annu. Rev. Immunol 31 : 107 ~ 135
[학술지(정기간행물)] - Lo Re, S. / 2010 / IL-17A-producing gammadelta T Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis / J. Immunol 184 : 6367 ~ 6377
[학술지(정기간행물)] - Sonnenberg, G. F. / 2010 / Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A / J. Exp. Med 207 : 1293 ~ 12305
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UCI(KEPA) : I410-ECN-0101-2016-511-001754673