지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 217 - 227 (11page)
- DOI
- 10.14815/kjdm.2015.42.3.217
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초록· 키워드
오류제보하기
Sustained drug release of hollow HA was investigated. HA slurry was prepared with amount of 30-70% HA(H groups) and sodium chloride up to 15%(N groups). Alginate beads were coated with HA slurry and burned out. In order to insert vancomycin-laden PLGA nanoparticles into hollow HA granules, vacuum pressure was applied. Drug release rates of vancomycin from HA/PLGA complex were monitored.
Size of HA spherical granules was controlled by injecting size or dropping speed into liquid nitrogen. Internal empty space that formed by burning out alginate beads during sintering was connected to external surface through pores in the shell. In H groups, increasing the ratio between HA and water, thickness of shell was increased, while the pore size and porosity was decreased because pores were formed as water frozen and subsequent sublimation of ice inside the shell. Addition of sodium chloride did not affect pore size and porosity in N groups. However, irregular-shaped pores were caused because sodium chloride that remains after the lyophilization burns out during the sintering. This played a role in delay the initial burst out of the drug.
In conclusion, tailoring the structure of pore channels between internal space and external surface was the key to control the sustained drug release rate.
Size of HA spherical granules was controlled by injecting size or dropping speed into liquid nitrogen. Internal empty space that formed by burning out alginate beads during sintering was connected to external surface through pores in the shell. In H groups, increasing the ratio between HA and water, thickness of shell was increased, while the pore size and porosity was decreased because pores were formed as water frozen and subsequent sublimation of ice inside the shell. Addition of sodium chloride did not affect pore size and porosity in N groups. However, irregular-shaped pores were caused because sodium chloride that remains after the lyophilization burns out during the sintering. This played a role in delay the initial burst out of the drug.
In conclusion, tailoring the structure of pore channels between internal space and external surface was the key to control the sustained drug release rate.
목차
〈Abstract〉
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
Ⅴ. CONCLUSIONS
REFERENCES
참고문헌 (45)
참고문헌 신청
[단행본] - Alexander H / 1987 / CRC critical reviews / CRC Press : 43 ~
[학술지(정기간행물)] - Babensee JE / 2000 / Growth factor delivery for tissue engineering / Pharm Res 11 : 47 ~ 58
[학술지(정기간행물)] - Boden SD / 1999 / Bioactive factors for bone tissue engineering / Clin Orthop 367 : S84 ~ S94
[학술지(정기간행물)] - Boonsongrit Y / 2008 / Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system / Mater Sci Eng B 148 : 162 ~ 165
[학술지(정기간행물)] - Cerroni L / 2002 / Growth of osteoblast like cells on porous hydroxyapatite ceramics : an in vitro study / Biomol Eng 19 : 119 ~ 124
[학술지(정기간행물)] - Babensee JE / 2000 / Growth factor delivery for tissue engineering / Pharm Res 11 : 47 ~ 58
[학술지(정기간행물)] - Boden SD / 1999 / Bioactive factors for bone tissue engineering / Clin Orthop 367 : S84 ~ S94
[학술지(정기간행물)] - Boonsongrit Y / 2008 / Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system / Mater Sci Eng B 148 : 162 ~ 165
[학술지(정기간행물)] - Cerroni L / 2002 / Growth of osteoblast like cells on porous hydroxyapatite ceramics : an in vitro study / Biomol Eng 19 : 119 ~ 124
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UCI(KEPA) : I410-ECN-0101-2016-515-001905456