지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 66 - 72 (7page)
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초록· 키워드
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Objectives: Uric acid concentration is known to increase the prevalence of metabolic syndrome by affecting its components, resulting in increased risk of cerebrovascular and cardiovascular diseases, and long-term lead exposure is known to affect this serum uric acid level. In this study, we aimed to examine the association between the causes of hyperuricemia and metabolic syndrome, and to determine whether an increased blood lead level affects hyperuricemia.
Method: Anthropometric measurements, surveys, and blood tests were conducted between May and June 2012 in 759 men working in the steelmaking process at a domestic steel company. Workers were divided into 2 groups according to the presence or absence of hyperuricemia, and an analysis was performed to examine its association with metabolic syndrome. In addition, the workers were divided into 3 groups according to the blood lead level to analyze the association between blood lead and hyperuricemia.
Results: The geometric mean (standard deviation) of the blood lead levels in the hyperuricemia group was significantly higher than that of the healthy group (3.8 [1.8] vs. 3.3 [1.8] μg/dL). The adjusted odds ratio for metabolic syndrome of the hyperuricemia group increased significantly to 1.787 (1.125?2.839) compared with the healthy group. In addition, the adjusted odds ratios for the occurrence of hyperuricemia in the tertile 2 (2.61?4.50 μg/dL) and tertile 3 groups (>4.50 μg/dL) according to blood lead level significantly increased to 1.763 (1.116?2.784) and 1.982 (1.254?3.132), respectively, compared with the tertile 1 group (< 2.61 μg/dL).
Conclusion: Hyperuricemia is believed to function as an independent risk factor for metabolic syndrome, while lead seems to increase the serum uric acid level even at a considerably low blood level. Therefore, attention should be given to patients with hyperuricemia and metabolic syndrome who are prone to lead exposure, and a prospective study should be conducted to identify their causal relationship.
Method: Anthropometric measurements, surveys, and blood tests were conducted between May and June 2012 in 759 men working in the steelmaking process at a domestic steel company. Workers were divided into 2 groups according to the presence or absence of hyperuricemia, and an analysis was performed to examine its association with metabolic syndrome. In addition, the workers were divided into 3 groups according to the blood lead level to analyze the association between blood lead and hyperuricemia.
Results: The geometric mean (standard deviation) of the blood lead levels in the hyperuricemia group was significantly higher than that of the healthy group (3.8 [1.8] vs. 3.3 [1.8] μg/dL). The adjusted odds ratio for metabolic syndrome of the hyperuricemia group increased significantly to 1.787 (1.125?2.839) compared with the healthy group. In addition, the adjusted odds ratios for the occurrence of hyperuricemia in the tertile 2 (2.61?4.50 μg/dL) and tertile 3 groups (>4.50 μg/dL) according to blood lead level significantly increased to 1.763 (1.116?2.784) and 1.982 (1.254?3.132), respectively, compared with the tertile 1 group (< 2.61 μg/dL).
Conclusion: Hyperuricemia is believed to function as an independent risk factor for metabolic syndrome, while lead seems to increase the serum uric acid level even at a considerably low blood level. Therefore, attention should be given to patients with hyperuricemia and metabolic syndrome who are prone to lead exposure, and a prospective study should be conducted to identify their causal relationship.
목차
Abstract
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (44)
참고문헌 신청
Statistics Korea / 2011 / Causes of Death Statistics in 2011
Ministry of Employment and Labor / 2011 / Analysis of the industrial disaster status in Korea 2011
Dekker JM / 2005 / Metabolic syndrome and 10-year cardiovascular disease risk in the hoorn study / Circulation 112:666~673
Chan WP / 2008 / Management of the metabolic syndrome in cardiovascular disease / Curr Treat Options Cardiovasc Med 10:27~38
Feig DI / 2008 / Uric acid and cardiovascular risk / N Engl J Med 359:1811~1821
Ministry of Employment and Labor / 2011 / Analysis of the industrial disaster status in Korea 2011
Dekker JM / 2005 / Metabolic syndrome and 10-year cardiovascular disease risk in the hoorn study / Circulation 112:666~673
Chan WP / 2008 / Management of the metabolic syndrome in cardiovascular disease / Curr Treat Options Cardiovasc Med 10:27~38
Feig DI / 2008 / Uric acid and cardiovascular risk / N Engl J Med 359:1811~1821
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UCI(KEPA) : I410-ECN-0101-2016-517-001952940