지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.3
- 발행연도
- 2015.8
- 수록면
- 131 - 137 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: The objective of this study was to assess the clinical outcomes of pelvic exenteration for patients with primary locally advanced colorectal cancer (LACRC) or locally recurrent colorectal cancer (LRCRC), and to identify clinically relevant prognostic factors.
Methods: Between January 2001 and December 2010, 40 consecutive patients with primary LACRC or LRCRC underwent pelvic exenteration at the National Cancer Center, Republic of Korea. We retrospectively reviewed their medical records.
Results: The median age was 59 years and the median follow-up time was 26 months (range, 1?117 months). The overall complication and in-hospital mortality rates were 70% (28/40) and 7.5% (3/40), respectively. The complication rates were similar between patients with primary LACRC (69.6%) and those with LRCRC (70.6%). The overall recurrence rate was 50% (17/34), and was lower in patients with primary LACRC than in patients with LRCRC (33.3% vs. 76.9%, P = 0.032). The 5-year overall survival was significantly different between primary LACRC and patients with LRCRC (58.7% vs. 11.8%, P = 0.022). Multivariate analysis revealed that radicality (R0 vs. R1/R2) was an independent prognostic factor for overall survival (P = 0.020).
Conclusion: The complication and operative mortality rates of pelvic exenteration remained high, but pelvic exenteration might provide an opportunity for long-term survival and good local control. Complete (R0) resection was the only independent prognostic factor for overall survival.
Methods: Between January 2001 and December 2010, 40 consecutive patients with primary LACRC or LRCRC underwent pelvic exenteration at the National Cancer Center, Republic of Korea. We retrospectively reviewed their medical records.
Results: The median age was 59 years and the median follow-up time was 26 months (range, 1?117 months). The overall complication and in-hospital mortality rates were 70% (28/40) and 7.5% (3/40), respectively. The complication rates were similar between patients with primary LACRC (69.6%) and those with LRCRC (70.6%). The overall recurrence rate was 50% (17/34), and was lower in patients with primary LACRC than in patients with LRCRC (33.3% vs. 76.9%, P = 0.032). The 5-year overall survival was significantly different between primary LACRC and patients with LRCRC (58.7% vs. 11.8%, P = 0.022). Multivariate analysis revealed that radicality (R0 vs. R1/R2) was an independent prognostic factor for overall survival (P = 0.020).
Conclusion: The complication and operative mortality rates of pelvic exenteration remained high, but pelvic exenteration might provide an opportunity for long-term survival and good local control. Complete (R0) resection was the only independent prognostic factor for overall survival.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Winter DC. / 2007 / Local involvement of the urinary bladder in primary colorectal cancer : outcome with enbloc resection / Ann Surg Oncol 14 : 69 ~ 73
[학술지(정기간행물)] - Pawlik TM. / 2006 / Pelvic exenteration for advanced pelvic malignancies / Ann Surg Oncol 13 : 612 ~ 623
[학술지(정기간행물)] - Rahbari NN. / 2011 / Surgery for locally recurrent rectal cancer in the era of total mesorectal excision : is there still a chance for cure? / Ann Surg 253 : 522 ~ 533
[학술지(정기간행물)] - Wanebo HJ. / 1999 / Pelvic resection of recurrent rectal cancer : technical considerations and outcomes / Dis Colon Rectum 42 : 1438 ~ 1448
[학술지(정기간행물)] - Brunschwig A. / 1948 / Complete excision of pelvic viscera for advanced carcinoma; a one-stage abdominoperineal operation with end colostomy and bilateral ureteral implantation into the colon above the colostomy / Cancer 1 : 177 ~ 183
[학술지(정기간행물)] - Pawlik TM. / 2006 / Pelvic exenteration for advanced pelvic malignancies / Ann Surg Oncol 13 : 612 ~ 623
[학술지(정기간행물)] - Rahbari NN. / 2011 / Surgery for locally recurrent rectal cancer in the era of total mesorectal excision : is there still a chance for cure? / Ann Surg 253 : 522 ~ 533
[학술지(정기간행물)] - Wanebo HJ. / 1999 / Pelvic resection of recurrent rectal cancer : technical considerations and outcomes / Dis Colon Rectum 42 : 1438 ~ 1448
[학술지(정기간행물)] - Brunschwig A. / 1948 / Complete excision of pelvic viscera for advanced carcinoma; a one-stage abdominoperineal operation with end colostomy and bilateral ureteral implantation into the colon above the colostomy / Cancer 1 : 177 ~ 183
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