지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 5 - 8 (4page)
이용수
초록· 키워드
오류제보하기
Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.
목차
INTRODUCTION
PRESENTATION SUMMARIES
CONCLUSION
REFERENCES
참고문헌 (4)
참고문헌 신청
Sauer, J.M., Hartung, T., Leist, M., Knudsen, T.B., Hoeng, J. and Hayes, A.W. (2015) Systems toxicology: the future of risk assessment. Int. J. Toxicol., 34, 346-348.
Hartung, T., van Vliet, E., Jaworska, J., Bonilla, L., Skinner, N. and Thomas, R. (2012) Systems toxicology. Altex, 29, 119- 128.
Sturla, S.J., Boobis, A.R., FitzGerald, R.E., Hoeng, J., Kavlock, R.J., Schirmer, K., Whelan, M., Wilks, M.F. and Peitsch, M.C. (2014) Systems toxicology: from basic research to risk assessment. Chem. Res. Toxicol., 27, 314-329.
Miller, R.M., Callahan, L.M., Casaceli, C., Chen, L., Kiser, G.L., Chui, B., Kaysser-Kranich, T.M., Sendera, T.J., Palaniappan, C. and Federoff, H.J. (2004) Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned mouse substantia nigra. J. Neurosci., 24, 7445- 7454.
Hartung, T., van Vliet, E., Jaworska, J., Bonilla, L., Skinner, N. and Thomas, R. (2012) Systems toxicology. Altex, 29, 119- 128.
Sturla, S.J., Boobis, A.R., FitzGerald, R.E., Hoeng, J., Kavlock, R.J., Schirmer, K., Whelan, M., Wilks, M.F. and Peitsch, M.C. (2014) Systems toxicology: from basic research to risk assessment. Chem. Res. Toxicol., 27, 314-329.
Miller, R.M., Callahan, L.M., Casaceli, C., Chen, L., Kiser, G.L., Chui, B., Kaysser-Kranich, T.M., Sendera, T.J., Palaniappan, C. and Federoff, H.J. (2004) Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned mouse substantia nigra. J. Neurosci., 24, 7445- 7454.
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UCI(KEPA) : I410-ECN-0101-2016-513-002334008